Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...
Patent
1996-07-17
1998-03-10
Spivack, Phyllis G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Phosphorus containing other than solely as part of an...
514103, 514171, 514738, A61K 31685, A61K 3166, A61K 31575, A61K 31045
Patent
active
057261636
DESCRIPTION:
BRIEF SUMMARY
This application claims benefit of international application PCT/JP 95/00045, filed Jan. 19, 1995.
TECHNICAL FIELD
The present invention relates to a dermatologic composition whose barrier property on the skin surface has been heightened by mixing a specific phospholipid, a cholesterol, a diol having a molecular weight of 430 or less and an oily ingredient.
BACKGROUND ART
In the rough skin or dry skin, the barrier function of stratum corneum deteriorates, thereby resulting in an increase of the transepidermal water loss (hereinafter, referred to as "TEWL"). Also in the case of patients suffering from atopic dermatitis which is a disease attracting much attention in recent days, the barrier function of stratum corneum deteriorates, thereby increasing the TEWL.
To improve the above-described state, it has been the conventional practice to apply a plugging type base material such as vaseline which inhibits TEWL. In this case, however, the plugging type base material has uncomfortable touch feeling such as oiliness and stickiness so that it involves a problem in feeling upon use.
DISCLOSURE OF THE INVENTION
As a result of an extensive investigation, the present inventors have paid attention to the fact that a specific phospholipid not only has strong resistance to oxidation but also is colorless and odorless, and is stable with the passage of time. It has been found that a dermatologic composition, which can inhibit TEWL, is free from discoloration and odor, and has excellent feeling upon use, can be obtained by using the above specific phospholipid in combination with a cholesterol, a diol having a molecular weight of 430 or less and an oily ingredient, thus completing the invention.
The present invention therefore provides a dermatologic composition which comprises a hydrogenated phospholipid having an iodine value of 10 or less and a phosphatidylcholine content of 90% or more (hereinafter, referred to as "specific phospholipid"), a cholesterol, a diol having a molecular weight of 430 or less and an oily ingredient.
As a source for the specific phospholipid suitable for use in the present invention, any one of soybean, yolk, synthetic products and semisynthetic products can be used. The specific phospholipid is added in an amount of from 0.01 wt % to 30 wt % based on the total amount of the composition.
The cholesterol is added at a ratio ranging from 1:0.01 to 1:50 relative to the specific phospholipid. Outside the above range, the advantage of the present invention cannot be obtained.
The diol having a molecular weight of 430 or less is employed to improve the compatibility of the specific phospholipid with other ingredients, thereby providing a composition having good emulsion stability. Examples of the diol include 1,3-butylene glycol, propylene glycol and dipropylene glycol. They may be used either singly or in combination. They are added in an amount of from 0.1 wt % to 10 wt % based on the total amount of the composition.
Examples of the oily ingredient include vegetable oils such as olive oil, avocado oil and castor oil; animal oils such as beef tallow, turtle oil, mink oil and horse oil; semisynthetic or synthetic oils or fats such as hydrogenated beef tallow, glyceryl triisooctanoate and hydrogenated horse oil; vegetable ester oils such as carnauba wax, candelilla wax and jojoba oil, animal-vegetable ester oils such as beeswax, lanolin and whale oil; synthetic ester oils such as cetyl isooctanoate, isopropyl myristate, octyldodecyl myristate, neopentyl glycol dicaprate and cholesterol hydroxy stearate; hydrocarbons such as liquid paraffin, paraffin, microcrystalline wax, ceresin and squalane; synthetic oils such as liquid polyisobutylene and silicone oil; and oil-soluble vitamins such as vitamin E acetate and vitamin A oil. Of these oily ingredients, oils in the form of liquid are preferred, with neopentyl glycol dicaprate, squalane and silicone oil being most preferred. The above oily ingredient is added at a ratio of from 1:1 to 1:100 relative to the phospholipid. Outside the above range
REFERENCES:
Influence of Phospholipids Purity and Polyols on the Temperature Dependence of the Permeability of Liposomes, Kuni arakane et al, J.Soc. Cosmet. Chem. Japan, vol. 25, No. 3 1991, pp. 171-177.
Remington's Pharmaceutical Sciences, Fifteenth Ed., Mack Publishing Co., p. 1249 (1975).
Fujii Takako
Hasegawa Kazuo
Tanaka Shigeo
Urushizaki Fumio
Spivack Phyllis G.
Taisho Pharmaceutical Co. Ltd.
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