Drug – bio-affecting and body treating compositions – Fermentate of unknown chemical structure
Patent
1981-04-27
1985-03-05
Shapiro, Lionel M.
Drug, bio-affecting and body treating compositions
Fermentate of unknown chemical structure
435171, 435911, A61K 3572, C12P 102, C12R 172
Patent
active
045030413
DESCRIPTION:
BRIEF SUMMARY
TECHNOLOGICAL FIELD
The present invention relates to a dermatic medicament consisting solely of a sterile supernatant formed by filtering and sterilizing a culture liquid of a novel strain, Trichosporon kashiwayama strain (deposited at FRI with deposition No. 4821) (FERM-P No. 4821), which may be identified as a strain belonging to the genus Geotricum or Endomycopsis, according to customary procedures, or a concentrate or dry product formed from the sterile supernatant according to customary procedures, or a dermatic medicament comprising as the active ingredient the sterile supernatant or the concentrate or dry product incorporated into a carrier such as an ordinary skin cream or ointment base.
The strain will be permanently available to the public if a patent is granted. Access to the patent application will be available to one determined by the Commissioner to be entitled thereto under 37 C.F.R. 1.14 and 35 U.S.C. 122 and all restrictions on the availability to the public of the culture will be irrevocably removed upon the grant of the patent.
BACKGROUND OF THE INVENTION
The microorganism that is used in the present invention, that is, Trichosporon kashiwayama strain, is considered to belong to yeast, but the strain sometimes is classified as a fungi imperfecti. Accordingly, the statement that the strain may be identified as a strain belonging to the genus Geotricum or Endomycopsis is based on the scientific concept held by experts in the art.
As is seen from the accompanying drawings (photographs), the strain that is used in the present invention is characterized in that it has bead-like arthrospores and pseudomycelia. Moreover, the strain is characterized in that a fermentation product of the strain, that is, a supernatant of a culture liquid of the strain, has by itself a prominent medicinal effect to the human skin.
DESCRIPTION OF THE INVENTION
The effective substance which exerts a medicinal effect is still unknown. However, if a sterile supernatant of a culture liquid of the strain or a concentrate or dry product is applied to the skin as it is or after it has been mixed with an appropriate carrier and formed into a preparation suitable for application to the human skin, for example, an ointment, the following medicinal effects can be attained.
(1) The fermentation liquid is weakly acidic (having a pH value of 4.5 to 5.0) and is non-toxic to the skin, and it promotes the skin-protecting action of the fat membrane, especially the bacterium controlling action inherent of the fat membrane.
(2) Excessive peeling of keratine pieces from the horny layer is prevented and simultaneously, an appropriate water content is maintained in the horny layer, and therefore, the characteristics of the skin per se such as dampness and elasticity can be maintained in good conditions.
(3) The lipid metabolism of epidermal cells is controlled to promote appropriate formation of keratin and smooth propagation and differentiation of epidermal cells.
(4) Especially to the fatty skin, excessive secretion of sebum is controlled and increase of the thickness of the fat membrane is prevented. Accordingly, diffusion of sebum to the skin surface from the hair follicle is promoted and a preventive effect to fatty dermatitis such as acne is obtained.
(5) Since collagen fibers of the statum reticulate are reinforced or swollen to maintain an appropriate water content in the upper layers, good and normal hardness and elasticity are retained in the skin.
(6) Since circulation of blood is improved, metabolism of the skin is promoted, and transportation of skin waste matters to the veins and excretion are promoted. Simultaneously, excretion of melanin color to the outside of the body is expedited.
(7) To the skin diseases caused by oxidation under actinic rays, the fermentation liquid or sterile supernatant acts as an antioxidant for the fatty membrane and promotes discoloration of abnormally deposited melanin color in skin spots or the like. When the fermentation liquid or sterile supernatant is administered in combination with
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