Dermal-epidermal in vitro test system

Details Dermal-epidermal in vitro test system Dermal-epidermal in vitro test system

1995-05-16

1998-05-26

Isabella, David

Prosthesis (i.e., artificial body members), parts thereof, or ai

Miscellaneous

4352401, 673 15, A61F 210, A61K 3512

Patent

active

057558140

ABSTRACT:
This invention relates to a skin model system that can be used as an in vitro test system or which can be used for therapeutic purposes. The skin model system comprises a three-dimensional, cross-linked matrix of insoluble collagen containing fibroblast cells therein, and stratified layers of differentiated epidermal cells supported thereon.

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Dykes, et al., "In Vitro Reconstruction of Human Skin: The Use of Skin Equivalents as Potential Indicators of Cutaneous Toxicity", Toxic. In Vitro, 1991, 5, 1-8.
Leighton, et al., "Patterns of Three-dimensional Growth in Vitro in Collagen-coated Cellulose Sponge: Carcinomas and Embryonic Tissues", Cancer Research, 1968, 28, 286-296.
Bell et al., "The Reconstitution of Living Skin", Journal of Investigative Dermatology 1983, 81, 2s-10s.
Doillon et al., "Behavior of Fibroblasts and Epidermal Cells Cultivated on Analogues of Extracellular Matrix", Biomaterials 1988, 9, 91-96.

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