Dermal-epidermal in vitro test system

Details Dermal-epidermal in vitro test system Dermal-epidermal in vitro test system

1995-06-07

1999-03-30

Isabella, Davidd

Prosthesis (i.e., artificial body members), parts thereof, or ai

Miscellaneous

4352401, 623 15, A61F 200, A61K 3512

Patent

active

058882480

ABSTRACT:
This invention relates to a skin model system that can be used as an in vitro test system or which can be used for therapeutic purposes. The skin model system comprises a three-dimensional, cross-linked matrix of insoluble collagen containing fibroblast cells therein, and stratified layers of differentiated epidermal cells supported thereon.

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Dykes, In Vitro Reconstruction of Human Skin: The Use Of Skin Equivalents as Potential Indicators
Dykes, TJ. "In Vitro Reconstruction of Human Skin; The use of Skin Equivalents as Potential Indicators of Cut Angus Toxicity" Toxic. in Vitro vols pp. 1-7, 1991.
Leighton, J. et al. Patterns of 3-D Growth in Vitro in Collagen-Coated Cellulose Sponge: Carcinomas and Embroyonic Tissues Cancer Research 28, 286-286. 1968.
Bell et al., "The Reconstitution of Living Skin", Journal of Investigative Dermatology 1983, 81, 2s-10s.
Doilllon et al., "Behavior of Fibroblasts and Epidermal Cells Cultivated on Analogues of Extracellular Matrix", Biomaterials 1988, 9, 91-96.

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