Derivatized pyridinoline reagent

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Albumin

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530404, 436 87, 436 88, 5462787, C07K 14765, C07K 14805, G01N 3368

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active

057566798

ABSTRACT:
A pyridinoline composition in which pyridinoline is derivatized specifically at its aliphatic hydroxyl group by a selected chemical group is disclosed. In various embodiments, the composition may be used as a standard for HPLC or immunoassay of pyridinoline, a pyridinoline immunogen for producing anti-pyridinoline antibodies, and a solid-phase reagent for use in an immunoassay kit. Also disclosed are methods for making and using the composition.

REFERENCES:
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patent: 5350855 (1994-09-01), Daniloff et al.
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Fujimoto, D., et al., "Analysis of Pyridinoline, a Cross-Linking Compound of Collagen Fibers, in Human Urine," J. Biochem. 94:1133-1136 (1983).
Hanson, D.A., and Eyre, D.R., "A Specific Immunoassay for Bone Resorption Based on Cross-Linked Collagen Peptides in Urine," Abstract from J. Bone & Mineral Res. 6(1):S251 (1991).
Previero, A., et al., "Specific O-Acylation of Hydroxylamino Acids in Presence of Free Amino Groups," Biochim. Biophys. Acta 263:7-13 (1972).
Robins S. P., et al., "Measurement of the cross linking compound, pyridinoline, in urine as an index of collagen degradation in joint disease," Ann. Rheumat. Dis. 45:969-973 (1986).
Robins, S.P., "An enzyme-linked immunoassay for the collagen cross-link pyridinoline," Biochem. J. 207:617-620 (1982).
Seibel, M.J., et al., "Urinary Hydroxy-pyridinium Crosslinks Provide Indices of Cartilage and Bone Involvement in Arthritic Diseases," J. Rheumatol. 16(7):964-970 (1989).

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