Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1994-04-28
1996-03-26
Rotman, Alan L.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
546261, 546291, 546294, 436819, 530404, 530405, 530406, 210635, C07D40112, C07D21355, C07D21371
Patent
active
055021972
ABSTRACT:
A pyridinoline composition in which pyridinoline is derivatized specifically at its aliphatic hydroxyl group by a selected chemical group is disclosed. In various embodiments, the composition may be used as a standard for HPLC or immunoassay of pyridinoline, a pyridinoline immunogen for producing anti-pyridinoline antibodies, and a solid-phase reagent for use in an immunoassay kit. Also disclosed are methods for making and using the composition.
REFERENCES:
patent: 4973666 (1990-11-01), Eyre
patent: 5350855 (1994-09-01), Daniloff et al.
Black, D., et al., "Quantitative Analysis of the Pyridinium Crosslinks of Collagen in Urine Using Ion-Paired Reversed-Phase High-Performance Liquid Chromatography," Anal. Biochem. 169:197-203 (1988).
Black, D., et al., "Urinary excretion of the hydroxypyridinium crosslinks of collagen in patients with rheumatoid arthritis," Ann. Rheumat. Dis. 48:641-644 (1989).
Eyre, D. R., et al., "Quantitation of Hydroxypyridinium Cross-links in Collagen by High-Performance Liquid Chromatography," Anal. Biochem. 137:380-388 (1984).
Fujimoto, D., et al., "Analysis of Pyridinoline, a Cross-Linking Compound of Collagen Fibers, in human Urine," J. Biochem. 94:1133-1136 (1983).
Hanson, D. A., and Eyre, D. R., "A Specific Immunoassay for Bone Resorption Based on Cross-Linked Collagen Peptides in Urine," Abstract from J. Bone & Mineral Res. 6(1):S251 (1991).
Previero, A., et al., "Specific O-Acylation of Hydroxylamino Acids in Presence of Free Amino Groups," Biochim. Biophys. Acta 263:7-13 (1972).
Robins, S. P., et al., "Measurement of the cross linking compound, pyridinoline, in urine as an index of collagen degradation in joint disease," Ann. Rheumat. Dis. 45:969-973 (1986).
Robins, S. P., "An enzyme-linked immunoassay for the collagen cross-link pyridinoline," Biochem. J. 207:617-620 (1982).
Seibel, M. J., et al., "Urinary Hydroxy-pyridinium Crosslinks Provide Indices of Cartilage and Bone Involvement in Arthritic Diseases," J. Rheumatol. 16(7):964-970 (1989).
Daniloff Yuri
Evans Brian J.
Lungard Robert
Pratt David A.
Robins Simon P.
Dehlinger Peter J.
Metra Biosystems, Inc.
Powers Vincent M.
Rotman Alan L.
LandOfFree
Derivatized pyridinoline reagent does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Derivatized pyridinoline reagent, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Derivatized pyridinoline reagent will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-916903