Derivatization of solid supports and methods for oligomer synthe

Coating processes – With post-treatment of coating or coating material – Plural film forming coatings wherein one coating contains a...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

427340, 4273855, B05D 136, B05D 302

Patent

active

059195231

ABSTRACT:
Methods and derivatized supports which are useful in solid-phase synthesis of peptides, oligonucleotides or other small organic molecules as well as arrays of ligands. The methods provide means to control the functional site density on a solid support. Some of the derivatized supports are polymer-coated or glycan-coated. Other methods for regenerating the surface of a used ligand array are also provided.

REFERENCES:
patent: 3531258 (1970-09-01), Merrifield et al.
patent: 4593029 (1986-06-01), Venuti et al.
patent: 4619970 (1986-10-01), Okamoto et al.
patent: 4728502 (1988-03-01), Hamill
patent: 4812512 (1989-03-01), Buenda et al.
patent: 5143854 (1992-09-01), Pirrung et al.
patent: 5258454 (1993-11-01), Berg et al.
patent: 5288514 (1994-02-01), Ellman
patent: 5324633 (1994-06-01), Fodor et al.
patent: 5451683 (1995-09-01), Barrett et al.
Dugave, C. et al., "Synthesis of Activated Disulfude Adducts Containing a 4-Diazocyclohexa-2, 5-dienone Precursor for Photaffinity Labelling," Tetra. Letts. 35(51):955-9560 (1994).
Fenech G. et al., Gazz. Chim. Ital. 91:163-172 (1961).
Fodor, S.P.A. et al., Science 251:767-773 (1991).
Fodor, S.P.A. et al., Nature 364:555-556 (1993).
Frank et al., Tetrahedron 44:6031-6040 (1988).
Geysen et al., J. Immun. Meth. 102:259-274 (1987).
Green, M. et al., Adv. Protein Chem. 29:85-133 (1975).
Greene, T.W. et al., Protective Groups of Organic Synthsis John Wiley, New York, pp. 1-362, see pp. 27, 62, 88, 89, 315, 349, and 362 (1991).
Holmes et al., "New Techniques in Random Screening," 12th Int'l Symp. on Medicinal Chemistry Basel, Switzerland (Sep. 13-17, 1992).
Jones, G.H. et al., "Inhibitors of Cyclic AMP Phosphodiesterase: 1.Analogs of cilostamide and anagrelide," Chem. Abstr. 106(13):102224 (1987); J. Med. Chem. 30(2):295-303 (1987) see compounds: 105763-67-5, 105763-74-4, 105763-73-3 and 105763-76-6.
Lofas, S. et al., J. Chem. Soc., Chem. Commun. 1526-1528 (1990).
Marengere, L.E.M. et al., Nature 502-505 (Jun. 9, 1994).
Nagakura, I. et al., Heterrocycles 3(6):453-457 (1975).
Payne, G. et al., Proc. Natl. Acad. Sci. U.S.A.4902-4906 (1993).
Rajasekhara Pillai, V.N. et al., "New, Easily Removable Poly(ethyleneglycol) Supports for the Liquid-Phase Method of Peptide Synthesis," J. Org. Chem. 45(26):5364-5370 (1980).
Rich, D.H. et al., J. Am. Chem. Soc. 97:1575-1579 (1975).
Surrey, A.R. et al., J. Am. Chem. Soc. 80:3469-3471 (1958).
Timofeev, E.N. et al., "Chemical Design in Gel-Based Shom," International Workshop on Sequencing by Hybridization, hosted by Houston Advanced Research Center DNA Technology Laboratory, (Oct. 29-30, 1993).
Wang, S.S. et al., J. Org. Chem. 41(20:3258-3261 (1976).
Abraham, N.A. et al., Tetra. Letts. 32(5):577-580 (1991).
Barany, G. et al., J. Am. Chem. Soc. 107:4936-4942 (1985).
Bellof, D. et al., Chimia 39(10):317-320 1985).
Bush et al., Amer. J. Optometry Physiol. Optics 65(9):722-728 (1988).
Cass, R. et al., Peptides: Chemistry, Structure and Biology pp. 975-977 (Jun. 20-25, 1993).
Cook, R.M. et al., Tetra. Letts. 35(37):6777-6780 (1994).
Dower et al., Ann. Rep. Med. Chem. 28:271-280 (1991).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Derivatization of solid supports and methods for oligomer synthe does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Derivatization of solid supports and methods for oligomer synthe, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Derivatization of solid supports and methods for oligomer synthe will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-897636

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.