Derivativized polysaccharides with biologic activity, method of

Details Derivativized polysaccharides with biologic activity, method of Derivativized polysaccharides with biologic activity, method of

1989-01-23

1991-10-15

Griffin, Ronald W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514885, 424 88, 424 89, 424 92, 424 858, 424 86, 424 87, A61K 3100, A61K 3900

Patent

active

050575031

ABSTRACT:
This invention relates to the discovery and isolation of the smallest biologically active polysaccharide which will interact with the .beta.-glucan receptors present on mammalian phagocytic cells. The invention additionally relates to methods of preparing this heptaglucoside, and uses of the molecule as an immunomodulator and an activating agent. The invention additionally relates to methods of separating biologically active polysaccharides from similar inactive forms, and improved methods of separating low molecular weight polysaccharides and isomers from one another.

REFERENCES:
Di Luzio et al., Int. J. Cancer 24: 773-779 (1979).
Sherwood et al., Int. Immunipharmacol. 9: 261-267 (1987).
Chihara et al., Cancer Detection Prevent. Suppl. 1:423-443 (1987).
Sharp et al., J. Biol. Chem. 259:11312-11320 (1984).
Sharp et al., J. Biol. Chem. 259:11321-11336 (1984).
Janusz et al., J. Immunol. 137:3270-3276 (1986).
Her et al., J. Carbohydr. Chem. 6:129-139 (1987).
Janusz et al., 4th International Conference of Immuno-pharmacology, Osaka, Japan, May 18, 1988.

Affiliated with

Also associated with

Rating

Derivativized polysaccharides with biologic activity, method of does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Derivativized polysaccharides with biologic activity, method of , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Derivativized polysaccharides with biologic activity, method of will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-991208