Derivatives with unsaturated substitutions for the 5'-hydroxymet

Details Derivatives with unsaturated substitutions for the 5'-hydroxymet Derivatives with unsaturated substitutions for the 5'-hydroxymet

1988-03-25

1991-02-26

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 24, C07H 19167, C07H 19173

Patent

active

049963082

ABSTRACT:
This invention relates to certain acetylenic, cyano and allenic aristeromycin/adenosine derivatives which are useful in inhibiting AdoMet-dependent transmethylation and in the treatment of patients afflicted with neoplastic or viral disease states.

REFERENCES:
patent: 3472837 (1969-10-01), Verheyden et al.
patent: 3910885 (1975-10-01), Moffatt et al.
Brimacombe, Angewandte Chemie Intl. Ed., 8(6), 401-468 (1969).
Cook et al., J. Am. Chem. Soc., 101, 1554-1564 (1979).
Jenkins et al., J. Am. Chem. Soc., 98(11), 3346-3357 (1976).
Richards et al., Carbohydrate Research, 100, 315-329 (1982).
Verheyden et al., Ann. N.Y. Acad. Sci., 255, 151-165 (1975).
Bennett et al., [Mol. Pharmacol., 29, 383 (1986)].
De Clercq, [Biochem. Pharmacol., 36, 2567-75 (1987)].
Ferrier, Advances in Carbohydrate Chemistry and Biochemistry, vol. 24, pp. 250-251 (1969).
Aarbakke et al., Cancer Res., 46, 5469 (1986).
Montgomery et al., J. Med. Chem., 25, 626 (1982).
Clercq et al., Antiviral Res., 3, 17 (1983).
Baker et al., Tetrahedron Letters, 30, 2939 (1974).
Craig et al., J. Orig. Chem., 51, 1258 (1986).
Jenkins et al., J. Amer. Chem. Soc., 98, 3346.

Affiliated with

Also associated with

Rating

Derivatives with unsaturated substitutions for the 5'-hydroxymet does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Derivatives with unsaturated substitutions for the 5'-hydroxymet, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Derivatives with unsaturated substitutions for the 5'-hydroxymet will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-294707