Derivatives of valproic acid amides and 2-valproenoic acid amide

Details Derivatives of valproic acid amides and 2-valproenoic acid amide Derivatives of valproic acid amides and 2-valproenoic acid amide

1993-07-06

1996-12-17

Gerstl, Robert

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

564155, 564159, C07K 5067, A61K 3805

Patent

active

055853587

ABSTRACT:
A compound having the structure: ##STR1## wherein R.sub.1, R.sub.2, and R.sub.3 are independently the same or different and are hydrogen, a C.sub.1 -C.sub.6 alkyl group, an aralkyl group, or an aryl group, and n is an integer which is greater than or equal to 0 and less than or equal to 3. Also provided are a compound containing a 2-valproenoic moiety, pharmaceutical compositions comprising these compounds, and methods of using them for the effective treatment of epilepsy and other neurological disorders.

REFERENCES:
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Yu, Mol. & Chem Neuropath 15, 37 (1991).
Chemical Abstracts 101 (17), 143458v, 1984.
Drugs of the Future 9(8):587-588 (1984).
Drugs of the Future 16(8):775 (1991).
Haj-Yehia, A., et al., Pharmaceutical Research 6(8):683-689.
Bialer, M., et al., Eur. J. Clin. Pharmacol. 38:289-291 (1990).
Bialer, M., Clin. Pharmacokinet. 20(2):114-122 (1991).
Hadad, S., et al., Journal of Pharmaceutical Sciences 81(10):1047-1050 (1992).

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