Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1992-09-10
1996-05-21
Robinson, Douglas W.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
514 2, 514 25, 514 53, 514 54, 514 61, 514563, 536 5, 536 172, 536 173, 536 174, 536 175, 536 176, 536 181, 536 221, 536 55, 536 551, 552502, A01N 3700, A01N 3900, A61K 3100, A61K 3156
Patent
active
055190081
ABSTRACT:
Triterpenoid acid derivatives have been found to have structures similar to natural ligands to the extent that these derivatives bind to natural selectin receptors including endothelial leukocyte adhesion molecule-1 (ELAM-1) and leukocyte/endothelial cell adhesion molecule-1 (LECAM-1). The molecules can be administered to the patients by themselves or in pharmaceutical formulations; in order to alleviate inflammation and/or treat other abnormalities associated with the excessive binding of leukocytes to endothelial receptors.
REFERENCES:
patent: 4084010 (1978-04-01), Takemoto et al.
patent: 4568665 (1986-02-01), Mitchell
patent: 4987125 (1991-01-01), Han et al.
patent: 5019495 (1991-05-01), Shanbrom
patent: 5204324 (1993-04-01), Shanbrom
60-178898--Japan--no translation.
63-243093--Japan--no translation.
61-148142--Japan--no translation.
62-51604--Japan--nop translation.
4-190799--Japan--no translation.
3-271239--Japan--no translation.
Acta Pharmaceutica Sinica 1988; 23(7):553-560--no translation.
Baran, J. S. et al. (1974) J. Med. Chem. 17:2, 184-191.
Brieskorn, C. H. et al. (1970) Arch. der Pharmazie, 11:905-919.
Marsh, C. A., et al. (1956) J. Biochem. 63:9-14.
Lythogoe, B. et al. (1950) J. Chem. Society 63:1983-1991.
Louis, L. H. et al. (1956) J. Lab. Clin. Med. 47-1:20-28.
Ruzieka, L. et al. (1936) Helv. Chim. Acta. 19:1402-1406--no translation.
Karrer, P. et al. (1921) Helv. Chim. Acta. 4:100-113--no translation.
Soviet Union Issued Patent--SU1499-902-A; issued May 7, 1991--abstract only.
Soviet Union Issued Patent--SU1513-882-A; issued May 7, 1991--abstract only.
Ying, et al., "Inhibition of human leucocyte elastase by ursolic acid," Biochem. J. (1991) vol. 277, 521-526.
Taylor, "Bacterial Triterpenoids," Microb. Reviews., vol. 48, No. 3 (Sep. 1984) pp. 181-198.
Narasinga, B. N., et al., "Sialyl Lewis X Mimics Derived from a Pharmacore Search Are Selectin Inhibitors with Anti-Inflammatory Activity", J. Biol. Chemistry, 269:19663-19666 (1994).
Harlan, John M., et al., "In Vivo Models of Leukocyte Adherence to Endothelium", Ch. 6, 117-150 in Adhesion: Its Role in Inflammatory Response (1992).
Saitoh, Osamu, et al., "Differential Glycosylation and Cell Surface Expression of Lysosomal Membrane Glycoproteins in Sublines of a Human Colon Cancer Exhibiting Distinct Metastatic Potentials", J. Biol. Chemistry, 267:5700-5707 (1992).
Wattenberg, Lee, et al., "Cancer Chemoprevention", pp. 25-39 (1992).
Wattenberg, Lee, et al., "Cancer Chemoprevention", pp. 51-56 (1992).
Nishino, Hoyoku, "Antitumor-Promoting Activity of Glycyrrhetinic Acid and Its Related Compounds", Cancer Chemoprevention, pp. 457-467 (1992).
CA: 116: 40103f (1992) Nakamura.
CA 113: 103375g Kitagawa (1990).
CA 121(19): 231262v Saito (1994).
CA 115(2): 153673r Aquino (1991).
CA 113(2): 12139s Zen (1990).
J. Cell. Biol. 119(1) Erbe et al. (1992).
JACS 115, 7549-7550, De Frees (1993).
Anderson Mark B.
Musser John H.
Naleway John J.
Rao Narasinga
Glycomed Incorporated
Robinson Douglas W.
Wilson James Oliver
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