Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1995-06-06
1998-06-09
Kight, John
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
514 26, 514885, 514889, 536 185, C07H 15256, C07H 100
Patent
active
057635820
ABSTRACT:
Triterpenoid acid derivatives are described that exhibit dual pharmacophobic activities, specifically selectin ligand and leukotriene biosynthetic inhibitory activities, and that thus have significant applications for the treatment or prevention of certain diseases including cancer and diseases associated with the inflammatory process as well as applications for the diagnosis of disease.
REFERENCES:
patent: 3070623 (1962-12-01), Baxendale et al.
patent: 3070624 (1962-12-01), Baxendale et al.
patent: 3934027 (1976-01-01), Hans-Iurgen et al.
patent: 4173648 (1979-11-01), Pifferi et al.
patent: 5147859 (1992-09-01), Bombardelli et al.
patent: 5229378 (1993-07-01), Ogata et al.
patent: 5268364 (1993-12-01), Kojima et al.
patent: 5356880 (1994-10-01), Kurono et al.
patent: 5519008 (1996-05-01), Rao et al.
patent: 5527890 (1996-06-01), Rao et al.
patent: 5545623 (1996-08-01), Matsumori
Ahmad et al., A New Triterpene Glycoside from the Roots of Symphytum Officinale, CA Selects.RTM. Carbohydrates (Chemical Aspects), J. Natl. Prod., pp. 2-3 (1993).
Allevi et al., J. Chem. Soc. Perkin Trans. I, pp. 1275-1280 (1989).
Allevi et al., J. Chem. Soc. Chem. Commun., pp. 101-102 (1987).
Allevi et al., J. Chem. Soc. Chem. Commun., pp. 1245-1246 (1987).
Bertozzi et al., Antibody Targeting to Bacterial Cells Using Receptor-Specific Ligand/A Receptor-Mediated Immune Response Using Synthetic Glyconjugates, J. Am. Chem. Soc., 114:2242-5543 (1992).
Belvilacqua et al., Endothelial Leukocyte Adhesion Molecule 1: An Inducible Receptor for Neutrophils Related to Complement Regulatory Proteins and Lectins, Science, 243:1160-1165, (1989).
Borel et al., Molluscicidal Saponins from Swartzia Madagascariensis Desvaux, Helvetica Chimica Acta, 70:571-576 (1987).
Campsteyn et al., Crystal and Molecular Structure of Glycyrrhetinic Acid Acetone Monohydrate, Acta Cryst., B33:3443-3448 (1977).
Davidson et al., Glycyrrhetinic Acid Derivatives; A Novel Class of Inhibitors of Gap-Junctional Intercellular Communication, Structure-Activity Relationships, Journal of Pharmacology and Experimental Therapeutics, 246:3:1104-1107 (1988).
Ding et al., Constituents of Leguminous Plants, CA Selects.RTM. Carbohydrates (Chemical Aspects), Fac. Pharm. Sci., p. 11 (1993).
Doll et al., Clinical Trial of a Triterpenoid Liquorice Compound in Gastric and Duodenal Ulcer, Lancet, 11:793 (1962).
Egan et al., Inhibition of Mammalian 5-Lipoxygenase by Aromatic Disulfides, J. Biol. Chem., 260:11554-11559 (1985).
Goekjian et al., J. Org. Chem., vol. 56, pp. 6412-6422 (1991).
Grudzinskas et al., Prostaglandins and Congeners IV. The Synthesis of Certain 11-Substituted Derivatives of 11-Deoxyprostaglandin E.sub.2 and F.sub.2.alpha. From 15-O-Acetylprostaglandin A.sub.2 Methyl Ester, Tetrahedron Lett, 2:141-144 (1973).
Gundel et al., Endothelial Leukocyte Adhesion Molecule-1 Mediates Antigen-Induced Acute Airway Inflammation and Late-Phase Airway Obstruction in Monkeys, J. Clin. Invest., 88:1407-1411 (1991).
Harris et al., Cellular and Biochemical Characterization of the Anti-Inflammatory Effects of DuP 654 in the Arachidonic Acid Murine Skin Inflammation Model, Skin Pharmacol., 3:29-40 (1990).
Hirabayashi et al., Antiviral Activities of Glycyrrhizin and Its Modified Compounds Against Human Immunodeficient Virus Type I (HIV-1) and Herpes Simplex Virus Type 1 (HSV-1) In Vitro, Chem. Pharm. Bull., 39(1):223-115 (1991).
Inoue et al., Inhibitory Effect of Glycyrrhetinic Acid Derivatives on Lipoxygenase and Prostaglandin Synthetase, Chem. Pharm. Bull., 2:897-901(1986).
Lasky et al., Cloning of a Lymphocyte Homing Receptor Reveals a Lectin Domain, Cell, 56:1045-1055 (1989).
Levy et al., Cell Adhesion and Carbohydrates, Annual Reports in Medicine Chemistry, 29 (in press).
Mulligan et al., Protective Effects of Oligosaccharides in P-Selectin-Dependent Lung Injury, Nature, 364:149-151 (1993).
Mulligan et al., Role of Endothelial-Leukocyte Adhesion Module 1 (ELAM-1) in Neutrophil-Mediated Lung Injury in Rats, J. Clin. Invest., 88:1396-1406 (1991).
Romussi et al., Revised Structures of Triterpene Saponins from Anchusa Officinalis L, CA Selects.RTM. Carbohydrates (Chemical Aspects), Pharmazie, p. 4 (1993).
Schaub et al., Prostaglandins and Congeners II. The Conjugate Addition of 3-t-Butoxyoctyl Magnesium Bromide to Clycopentenone. A Synthesis of RAC 11-Deoxy-13-Dihydroprostaglandin-E.sub.1, Tetrahedron Lett, 2:129-130 (1973).
Springer et al., Nature, vol. 349, pp. 196-197 (1991).
Tedder et al., Isolation and Chromosomal Localization of cDNAs Encoding a Novel Human Lymphocyte Cell Surface Molecule, LAM-1, J. Exp. Med., 170:123-131 (1989).
Tyrrel et al., Proc. Natl. Acad. Sci. USA, vol. 88, pp. 10372-10376 (1991).
Yamada et al., Total Synthesis of Intensely Sweet Saponin, Osladin, CA Select.RTM. Carbohydrates (Chemical Aspects), Fac. Pharm. Sci., p. 5 (1993).
Anderson Mark Brian
Musser John Henry
Rao Narasinga
Glycomed Incorporated
Kight John
Lee Howard C.
LandOfFree
Derivatives of triterpenoid acids and uses thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Derivatives of triterpenoid acids and uses thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Derivatives of triterpenoid acids and uses thereof will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2200628