Derivatives of triazolyl-imidazopyridine and of the...

Details Derivatives of triazolyl-imidazopyridine and of the... Derivatives of triazolyl-imidazopyridine and of the...

2007-06-12

2007-06-12

Berch, Mark L. (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

C546S118000

Reexamination Certificate

active

10484491

ABSTRACT:
Compounds of formula (I)wherein: X is N;R1is C1–C6linear or branched alkyl or C1–C6linear or branched alkenyl; R2is hydrogen, C1–C6linear or branched alkyl or C1–C6linear or branched alkenyl, C6–C14aryl or C6–C14aryl(C1–C6) linear or branched alkyl or C6–C14aryl(C1–C6) linear or branched alkenyl, with the aryl group optionally substituted by one or more substituents, either the same or different, selected from the group consisting of halogen, hydroxy, C1–C6alkoxy linear or branched or C114 C6alkenyloxy linear or branched, amino, optionally mono- or disubstituted with C1–C6linear or branched alkyl; R3is NH2, NHR4; R4is C1–C6alkyl or C1–C6hydroxyalkyl, C1–C3alkoxyalkyl, amino(C1–C6)alkyl, where the amino group is optionally substituted with one or two C1–C3linear or branched alkyl groups, or with one or two C2–C3alkenyl groups C6–C14aryl or C6–C14aryl(C1–C6)alkyl, with the aryl group optionally substituted by one or more substituents, either the same or different, selected from the group consisting by halogen, hydroxy, C1–C6alkoxy linear or branched or C1–C6alkenyloxy linear or branched, amino, mono- or di-substituted with C1–C6alkyl linear or branched or C1–C6alkenyl linear or branched; and their pharmaceutically acceptable salts. These compounds are antagonists of the adenosine A2areceptor and useful as medicaments, in particular for the treatment of Parkinson's disease.

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