Derivatives of thiophene-2-carboxylic acid and their pharmaceuti

Details Derivatives of thiophene-2-carboxylic acid and their pharmaceuti Derivatives of thiophene-2-carboxylic acid and their pharmaceuti

1983-11-04

1986-05-20

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548336, A61K 31415, C07D40300

Patent

active

045902038

ABSTRACT:
The disclosure is directed to new derivatives of thiophene-2-carboxylic acid and the pharmaceutically acceptable acid or base addition salts thereof as well as to the process for the preparation thereof. The compounds of the invention have the structural formula ##STR1## in which R in position 3 or 4 of the thiophene nucleus is hydrogen, methyl, chlorine or bromine and R.sub.1 is hydrogen or C.sub.1 -C.sub.4 -alkyl. The compounds have a remarkably strong inhibitory effect on the thromboxane synthetase and are useful for the treatment of conditions such as inflammation, hypertension, thrombus, apoplexy, asthma, angina pectoris, ischemic heart diseases, ischemic conditions, migraine and vascular complications in connection with diabetes.

REFERENCES:
patent: 4087536 (1978-05-01), Budde et al.
Hartough, Thiophene and its Derivatives, Interscience Publishers, Inc., New York, (1952), p. 183.
Hofmann, Imidazole and its Derivatives, Part I Interscience Publishers, Inc., New York, (1953), p. 49.

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