Derivatives of thioformamide

Details Derivatives of thioformamide Derivatives of thioformamide

1990-08-23

1992-09-29

Richter, Johann

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514212, 514277, 514311, 514318, 514332, 514346, 514357, 514880, 514375, 540597, 546164, 546175, 546194, 546265, 546266, 546267, 546281, 546261, 546263, 546264, 546291, 546293, 546300, 546301, 546302, 546331, 546340, A61K 31435, A61K 3147, A61K 31445, C07D21506, C07D21172, C07D21184

Patent

active

051514362

ABSTRACT:
Therapeutically useful thioformamide derivatives of the formula: ##STR1## wherein R represents alkyl, Het represents pyrid-3-yl, isoquinolin-4-yl, tetrahydroquinolin-3-yl, quinolin-3-yl, pyridazin-4-yl, pyrimid-5-yl, thiazol-5-yl, thieno[2,3-b]-pyridin-5-yl, pyrazin-2-yl, indol-3-yl and thieno[3,2-b]-pyridin-6-yl, Y represents ethylene, methylene or a valency bond, and X represents carbonyl, hydroxymethylene, >C.dbd.NOR.sup.1, >C.dbd.NN(R.sup.1).sub.2 or >C.dbd.NN(R.sup.1)CON(R.sup.1).sub.2 in which R.sup.1 represents hydrogen or optionally substituted alkyl, benzyl, phenethyl, 1-naphthylmethyl, 2-naphthylmethyl or pyrid-3-ylmethyl, or two R.sup.1 substituents on the same nitrogen atom may together form an optionally substituted alkylene radical chain and salts thereof, processes for their preparation and compositions containing them are described.

REFERENCES:
patent: 5037835 (1991-08-01), Efflard et al.

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