Derivatives of thienyl- and furyl-substituted N-butyl and N-phen

Details Derivatives of thienyl- and furyl-substituted N-butyl and N-phen Derivatives of thienyl- and furyl-substituted N-butyl and N-phen

1979-02-02

1981-06-09

Love, Ethel G.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

548336, 548341, A01N 4350, C07D40300

Patent

active

042725453

ABSTRACT:
The compounds of the present invention are represented by the formula ##STR1## wherein R.sup.1 and R.sup.2 are the same or different and are optionally substituted furyl or thienyl the substituents independently selected from the group halo, C.sub.1 to C.sub.6 alkyl and C.sub.1 to C.sub.6 alkoxy or optionally substituted phenyl the substituents independently selected from the group halo, C.sub.1 to C.sub.4 alkyl, C.sub.1 to C.sub.4 alkoxy and trifluoromethyl; X is oxygen or sulfur; m is the integer 0; and n is the integer 2 or 3; and the antimicrobial acid addition salts thereof, with the proviso that when either R.sup.1 or R.sup.2 is said optionally substituted phenyl the other R.sup.1 or R.sup.2 is said optionally substituted furyl or thienyl.
The compounds are useful for combatting fungi, bacteria and protozoa. They also have spermatocidal and spermatostatic activity.

REFERENCES:
patent: 3658813 (1972-04-01), Godefroi et al.
patent: 3717655 (1973-02-01), Godefroi et al.
patent: 4017631 (1977-04-01), Janssen et al.
patent: 4045568 (1977-08-01), Walker
patent: 4062966 (1977-12-01), Gymer
patent: 4078071 (1978-03-01), Walker
patent: 4107314 (1978-08-01), Cox et al.
patent: 4123542 (1978-10-01), Walker

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