Derivatives of the tetanus toxin, process for their preparation

Details Derivatives of the tetanus toxin, process for their preparation Derivatives of the tetanus toxin, process for their preparation

1975-12-02

1977-06-14

Torrence, Dolph H.

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

260112R, A61K 3902

Patent

active

040297659

ABSTRACT:
The present invention relates to derivatives of tetanus toxin, a process for their preparation by treating an aqueous solution of tetanus toxin with an aliphatic mono- or dialdehyde, reacting the toxin, before or after the aldehyde treatment, with a denaturing agent in the presence of a compound reducing disulfide bridges obtaining the derivative of the light chain in the presence of the denaturing agent by way of protein-chemical isolation processes and suitably separating it from the denaturing agent, and compositions containing said derivatives.

REFERENCES:
patent: 3542920 (1970-11-01), Schwick et al.
patent: 3903262 (1975-09-01), Pappenhagen et al.
Azuma et al., Chemical Abstracts, vol. 78, 39687q, (1973).

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