Derivatives of the N .alpha.-arylsulphonylaminoacyl-p-amidinophe

Details Derivatives of the N .alpha.-arylsulphonylaminoacyl-p-amidinophe Derivatives of the N .alpha.-arylsulphonylaminoacyl-p-amidinophe

1987-01-23

1990-12-11

Springer, David B.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514255, 514423, 544390, 548530, 548536, 546319, A61K 3140, A61K 31445, A61K 31495, C07D20709, C07D21353, C07D23904

Patent

active

049771680

ABSTRACT:
N.alpha.-substituted derivatives of N.alpha.-arylsulphonylaminoacyl p-amidinophenylalaninamides, their preparation, their use as medicaments and intermediates for their synthesis.

REFERENCES:
B. Voigt and G. Wagner, Pharmazie 40 (1985) II 5, pp. 305-306, English Translation.
Thrombosis Research 39; 771-775, 1985; J. Hauptmann, Bridgitte Kaiser and F. Markwardt; Anticoagulant Action of Synthetic Tight Binding Inhibitors of Thrombin in Vitro and In Vivo.
Thrombosis Research 29; 635-642, 1983; J. Sturzebecher, F. Markwardt, B. Voight, G. Wagner and P. Walsmann; Cyclic Amides of Noc-Arylsulfonylaminoacylated 4-Amidinophenylalanine-Tight.
Guenther Wagner et al., Chemical Abstracts, vol. 98, 1983, p. 645, No. 107770b, Columbus, Ohio.
J. Stuerzebecher et al., "Cyclic Amides of Na-arylsulfonylaminoiacylated 4-amidinophenylalanine-Light Binding Inhibitors of Thrombin", Chemical Abstracts, vol. 99, 1983, p. 279, No. 18600z, Columbus, Ohio.
U. Griessbach et al., "Assay of Hirudin in Plasma Using a Chromogenic Thrombin Substrate", Chemical Abstracts, vol. 102, 1985, p. 229, No. 91802b, Columbus, Ohio.
J. Hauptmann et al., "Anticoagulant Action of Syntheric Tight Binding Inhibitors of Thrombin in Viro and in Vivo", Chemical Abstracts, vol. 104, 1986, p. 43, No. 475z, Columbus, Ohio.
B. Kaiser et al., "Pharmacological Characterization of a New Highly Effective Synthetic Thrombin Inhibitor", vol. 104, 1986 p. 31, No. 45508d, Columbus, Ohio.
B. Voigt et al., Diepharmazie "Synthese vom Nalpha-Benzyloxycarbonyl-4-amidinophenylalaninamiden als Thrombininhibitoren", vol. 40, No. 5, May 1985, pp. 305-306, Berlin Germany, C.A. vol. 102, 1985 p. 735 Abst. #25017y.

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