Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1993-12-17
1996-12-03
Veitenheimer, Erich E.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
47 58, 424405, 530326, A01N 2500, A01N 6302, C07K 700
Patent
active
055808522
ABSTRACT:
Certain specific derivatives of the 17-amino acid peptide tachyplesin has been found to have antimicrobial activity against plant pathogens. In a preferred embodiment, plant resistance to diseases caused by plant pathogens which are susceptible to these peptides is produced by inserting into the cells of a plant a gene whose expression causes production of one or more of the peptides of this invention in the plant in antimicrobial amounts.
REFERENCES:
Kawano, et al. (1990) Antimicrobial Peptide, Tachyplesin I, Isolated From Hemocytes of the Horseshoe Crab (Tachypleus tridentatus), The Journal of Biological Chemistry, vol. 265, No. 26, pp. 15365-15367.
Masuda, et al. (1992) A Novel Anti-HIV Synthetic Peptide, T-22[TYR.sup.5, 12, LYS.sup.7 -Polyphemusin II), Biochemical and Biophysical Research Communications, vol. 189, No. 2, pp. 845-850.
Matsuzaki, et al. (1991) Interactions of an antimicrobial peptide, tachyplesin I, with lipid membranes, Biochimica et Biophysica Acta, pp. 259-264.
Miyata, et al. (1989) Antimicrobial Peptides, Isolated from Horseshoe Crab Hemocytes, Tachyplesin II, and Polyphemusins I and II: Chemical Structures and Biological Activity, J. Biochem, vol. 106, No. 4, pp. 663-668.
Muta, et al. (1990) Tachplesins Isolated from Hemocytes of Southeast Asian Horseshoe Crabs (Carcinoscorpius rotundicauda and Tachyplesin gigas): Identification of a New Tachyplesin, Tachyplesin III, and a Processing Intermediate of its Precursor, J. Biochem., vol. 108, No. 2, pp. 261-266.
Nakamura, et al. (1988) Tachyplesin, a Class of Antimicrobial Peptide from the Hemocytes of the Horseshoe Crab (Tachypleus tridentatus), The Journal of Biological Chemistry, vol. 263, No. 32, pp. 16709-16713.
Ohta, et al. (1992) Mechanisms of Antibacterial Action of Tachyplesins and Polyphemusins, a Group of Antimicrobial Peptides Isolated from Horseshoe Crab Hemocytes, Antimicrobial Agents and Chemotherapy, vol. 36, No. 7, pp. 1460-1465.
Park, et al. (1992) Conformation of Tachyplesin I from Tachypleus tridentatus When Interacting with Lipid Matrices, Biochemistry, vol. 31, No. 48, pp. 12241-12247.
Shieh, et al. (1989) Synthesis and properties of tachyplesin I, a lipospolysaccharide-binding peptide, from Tachypleus tridentatus, Febs Letters, vol. 252, No. 1, 2, pp. 121-124.
Shigenaga, et al. (1990) Antimicrobial Tachyplesin Peptide Precursor, The Journal of Biological Chemistry, vol. 265, No. 34, pp. 21350-21354.
Tamamura, et al. (1993) A comparative study of the solution structures of tachyplesin I and a novel anti-HIV synthetic peptide, T22[Tyr.sup.5, 12, Lys.sup.7 ]-polyphemusin II), determined by nuclear magnetic resonance, Biochimica et Biophysica Acta, pp. 209-216.
Tamamura, et al. (1993) Antimicrobial Activity and Conformation of Tachyplesin I and Its Analogs, Chem. Pharm. Bull., vol. 41, No. 5, pp. 978-980.
Yonezawa, et al. (1992) Binding of Tachyplesin I to DNA Revealed by Footprinting Analysis: Significant Contribution of Secondary Structure to DNA Binding and Implication for Biological Action, Biochemistry, vol. 31, pp. 2998-3004.
Tamamura, et al. (1993) Anti-HIV Activity and Conformational Analysis of a Novel Synthetic Peptide, T22 ([TYR.sup.5, 12, LYS.sup.7 ]-Polyphemusin II), Thirteenth American Peptide Symposium, Abstracts, p. 2-96.
Finnegan et al. 1994. Bio/Technology. 12:883-888.
Potrykus. 1991. Annu. Rev. Plant Physiol. Plant Mol. biol. 42:205-225.
Sambrook et al. 1989. Molecular Cloning-A Laboratory Manual. 2nd Ed. pp. 11.2-11.19, 11.45-11.49, and 11.52-11.61.
Gordon-Kamm et al. 1990. The Plant Cell. 2:603-618.
Putnam Rebecca J.
Rao A. Gururaj
Pioneer Hi-Bred International , Inc.
Veitenheimer Erich E.
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