Derivatives of succinic and glutaric acids and analogs...

Details Derivatives of succinic and glutaric acids and analogs... Derivatives of succinic and glutaric acids and analogs...

2008-04-29

2008-04-29

Saeed, Kamal A. (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S080000, C514S419000, C514S559000, C548S469000, C548S503000, C548S506000, C548S494000, C562S405000

Reexamination Certificate

active

07365091

ABSTRACT:
The present invention relates to derivatives of succinic and glutaric acids and analogues thereof, having the following general formula:useful as inhibitors of PHEX. These derivatives are useful for promoting generation of bone mass and treating or preventing diseases or conditions associated with a phosphate metabolism defect. Methods for preparation and intermediates are also disclosed.

REFERENCES:
patent: 4168267 (1979-09-01), Petrillo, Jr.
patent: 4337201 (1982-06-01), Petrillo, Jr.
patent: 5362727 (1994-11-01), Robl
patent: 5380921 (1995-01-01), Ishikawa et al.
patent: 0 254 032 (1988-01-01), None
patent: 0 412 595 (1991-02-01), None
patent: 0 566 157 (1993-10-01), None
patent: 2372804 (1978-06-01), None
patent: 2377374 (1978-08-01), None
patent: WO 97/05865 (1997-02-01), None
patent: WO 99/11606 (1999-03-01), None
patent: WO 00/50580 (2000-08-01), None
patent: WO 02/15918 (2002-02-01), None
patent: WO 02/092128 (2002-11-01), None
patent: WO 03/084997 (2003-10-01), None
ADHR Consortium,Nat. Genetics, 26:345-348, 2000.
Atherton and Sheppard, In: The Peptides,Udenfriend and Meienhofer (Eds.), 9:1, Academic Press NY, 1987.
Balkenhohl et al.,Angew. Chem. Int. Ed. Engl., 35:2288-2337, 1996.
Beck et al.,J. Clin. Invest., 99:1200-1209, 1997.
Bellows et al.,Calcif. Tissue Int., 38:143-154, 1986.
Boileau et al., “Characterization of PHEX endopeptidase catalytic activity: identification of parathyroid-hormone-related peptide107-139as a substrate and osteocalcin, PPiand phosphate as inhibitors,”Biochem. J., 355:707-716, 2001.
Chapman et al., “Inhibition of matrix metalloproteinases by N-carboxyalkyl peptides,”J. Medicinal Chemistry, abstract, 36(26):4293-4301, 1993.
Du et al.,Genomics, 36:22-28, 1996.
Ecarat et al.,J. Bone Miner. Res., 7:215-220, 1992.
Econs and Drezner,N: Engl. J. Med., 330:1679-1681, 1994.
Elgazwy and Abdel-Sattar, “Facile synthesis of (R,R) and of (R,S) tricarballylic acid anhydride and imide derivatives,”Molecules, abstract, 5(4):665-673, 2000.
Fourine-Zaluski et al., “Differential recognition of ‘enkephalinase’ and angiotensin-converting enzyme by new carboxyalkyl inhibitors,”Life Sciences, 31:2947-2954, 1982.
Furka, In: Combinatorial peptide and nonpeptide libraries, Jung (Ed.), VCH Verlagsgasellschaft, Weinheim, 4:111-137, 1996.
Greene and Wuts, In: Protective groups in organic synthesis, John Wiley & Sons, Inc., NY, 1999.
Grieff et al.,Biochem. Biophys. Res. Commun., 231:635-639, 1997.
Guo and Quarles,J. Bone Miner. Res., 12:1009-1014, 1997.
Hermkens et al.,Tetrahedron, 52:4527-4554, 1996.
Ikeuchi et al.,J. Biomed. Mate.r Res., 60:61-69, 2002.
Jan de Beur et al.,J. Bone Miner. Res., 17:1102-1110, 2002.
Johnsson et al.,ASBMR 24thAnnual Meetingin San Antonio, Texas, USA, Pres. #1139, 2002.
Lajeunesse et al.,Kidney Int., 50:1531-1538, 1996.
Lipman et al.,J. Biol. Chem., 273:13729-13737, 1998.
Mimura et al., “A novel class of enkephalinase inhibitors containing a C-terminal sulfo group,”J. Med. Chem., 35:602-608, 1992.
Nesbitt et al.,J. Bone Miner. Res., 14:2027-2035, 1999.
Ovens et al.,J. Peptide Sci., 6:489-495, 2000.
Rinnova et al., “An expedient method for the solid-phase synthesis of alpha-aminoalkyl phosphonopeptides,”Tetrahedron Lett, abstract, 43(22):4103-4106, 2002.
Rivero et al., In: A practical guide to combinatorial chemistry, Czarnik (Eds.),American Chem. Soc. Pub., Washington DC, 10:281-307, 1997.
Roques et al.,Pharmacological Reviews, 45:87-146, 1993.
Rowe et al.,Genomics, 67:54-68, 2000.
Rowe, “The role of the phex gene (PEX) in families with X-linked hypophosphataemic rickets,”Curr. Opin Nephrol Hypertens, 7:367-376, 1998.
Ruchon et al.,J. Bone Miner. Res., 15:1440-1450, 2000.
Ruchori et al.,J. Histochem Cytochem., 46:1-10, 1998.
Schiavi and Moe,Curr. Opin. Nephrol. Hypertens., 11:423-430, 2002.
Serval et al., “In vitro and in vivo inhibition of N-acetyl-L-aspartyl-L-glutamate catabolism by N-acylated L-glutamate analogs,”J. Pharmacology and Experimental Therapeutics, abstract, 260(3):1093-1100, 1992.
Shimada et al.,Proc. Natl. Acad. Sci. USA, 98:6500-6505, 2001.
Strom et al.,Hum. Mol. Genet., 6:165-171, 1997.
Tenenhouse and Econs, In: The metabolic and molecular bases of inherited disease, Scriver et al. (Eds.), McGraw Hill Book Co., NY, 197:5039-5067, 2001.
Tenenhouse,Nephrol. Dial. Transplant, 14:333-341, 1999.
Terrett et al.,Tetrahedron, 51:8135-8173, 1995.
The HYP Consortium,Nat. Genet., 11:130-136, 1995.
Thompson and Ellman,Chem. Rev., 96:555-600, 1996.
Turner and Tanzawa,FASEB J., 11:355-364, 1997.
Vehof et al.,Plast. Reconstr. Surg., 108:434-443, 2001.
Vu et al.,J. Histochem. Cytochem., 47:323-336, 1999.
Whittaker et al.,Chem. Rev., 99:2735-2776, 1999.
Yoshida et al.,J. Dent. Res., 78:217-220, 1999.

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