Derivatives of substituted N-alkyl imidazoles

Details Derivatives of substituted N-alkyl imidazoles Derivatives of substituted N-alkyl imidazoles

1976-03-08

1977-08-30

Trousof, Natalie

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

542426, 542413, 542431, 548341, 542470, 542400, A61K 31415, C07D23360

Patent

active

040455688

ABSTRACT:
Compounds of the formula ##STR1## wherein one of R.sup.1 and R.sup.2 is phenyl, phenyl straight chain lower alkyl or phenyl straight chain lower alkenyl or one of the above substituted in the phenyl ring with one or more substituents independently selected from the group consisting of lower alkyl of from one to four carbon atoms, halo and trifluoromethyl; the other of R.sup.1 and R.sup.2 is alkyl, cyclohexyl, cyclohexyl lower alkyl or cyclohexyl substituted with from 1 to 3 lower alkyl groups; X is oxygen or sulfur; n is an integer of from 1 to 8 with the proviso that n is not 1 when R.sup.1 is phenyl or substituted phenyl; and the antimicrobial acid addition salts thereof are useful as antifungal, antibacterial and antiprotozoal agents.

REFERENCES:
patent: 3658813 (1972-04-01), Godefroi et al.
patent: 3682951 (1972-08-01), Kreider
patent: 3717655 (1973-02-01), Godefroi et al.
patent: 3796704 (1974-03-01), Metzger et al.
Conant et al. The Chemistry of Organic Compounds revised edition p. 264 N. Y., MacMillan, 1939.

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