Derivatives of substituted imidazol-2-one and process for their

Details Derivatives of substituted imidazol-2-one and process for their Derivatives of substituted imidazol-2-one and process for their

1993-06-14

1995-03-28

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514304, 546112, 546125, C07D40104, C07D45104, C07D45114, A61K 3146

Patent

active

054017505

ABSTRACT:
Derivatives of 1-phenyl-3-azabicycloalkylimidazolidin-2-ones are provided of general formula (I) ##STR1## in which inter alia R.sub.3 represents a group ##STR2## wherein n is an integer of 1 or 2 and R.sub.8 is hydrogen, C.sub.1 -C.sub.6 alkyl unsubstituted or substituted by phenyl, C.sub.2 -C.sub.4 alkenyl, C.sub.2 -C.sub.4 alkynyl, formyl or C.sub.2 -C.sub.6 alkanoyl; and the pharmaceutically acceptable salts thereof, which are useful in the treatment of CNS disorders, gut motility disorders, emesis and migraine, as cognition activators, anti-drug addition agents and analgesic.

REFERENCES:
patent: 3702327 (1972-11-01), Pengmann
Journal of Medicinal Chemistry, vol. 33, No. 7, 1990, pp. 1932-1935.
Journal of Medicinal Chemistry, vol. 34, 1991, pp. 140-151.
Journal of Medicinal Chemistry, vol. 33, No. 6, 1990, pp. 1594-1600.
Derwent Publications Ltd, Abstract of U.S. 3,446,816, American Cyanamid, Issued on May 27, 1969.
Derwent Publications Ltd, Abstract of U.S. 5,600,430, Ely Lilly, Issued on Jul. 15, 1987.
Journal of Medicinal Chemistry, vol. 33, pp. 1929-1932 (1990).

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