Derivatives of substituted imidazol-2-one and process for their

Details Derivatives of substituted imidazol-2-one and process for their Derivatives of substituted imidazol-2-one and process for their

1992-02-28

1993-09-07

Cintins, Marianne M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546133, 514810, 514872, C07D21172, A61K 3144

Patent

active

052429296

ABSTRACT:
Derivatives of 1-phenyl-3-azabicycloalkylimidazolidin-2-ones are provided of general formula (1) ##STR1## in which inter alia R represents a group ##STR2## wherein n is an integer of 1 or 2 and R.sub.8 is hydrogen, C.sub.1 -C.sub.6 alkyl unsubstituted or substituted by phenyl, C.sub.2 -C.sub.4 alkenyl, C.sub.2 -C.sub.4 alkynyl, formyl or C.sub.2 -C.sub.6 alkanoyl; and the pharmaceutically acceptable salts thereof. which are useful in the treatment of CNS disorders, gut motility disorders, emesis and migraine, as cognition activators, anti-drug addition agents and analgesic.

REFERENCES:
patent: 3702327 (1972-11-01), Pengman et al.
Journal of Medicinal Chemistry, vol. 33, No. 7, 1990, pp. 1932-1935.
Journal of Medicinal Chemistry, vol. 34, 1991, pp. 140-151.
Journal of Medicinal Chemistry, vol. 33, No. 6, 1990, pp. 1594-1600.
Derwent Abstract of U.S. Pat. No. 3,446,816, American Cyanamidm, issued on May 27, 1969.
Derwent Abstract of European Patent No. A 0268229, Tanabe Seiyaku, published on May 25, 1988.
Derwent Abstract of U.S. Pat. No. 4,600,430, Ely Lilly, issued on Jul. 15, 1987.
Derwent Abstract of Japanese publication No. 1033172-Kotobuki Seyaku, published on Feb. 17, 1986.

Affiliated with

Also associated with

Rating

Derivatives of substituted imidazol-2-one and process for their does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Derivatives of substituted imidazol-2-one and process for their , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Derivatives of substituted imidazol-2-one and process for their will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-488010