Derivatives of substituted 4-biarylbutyric acid as matrix metall

Details Derivatives of substituted 4-biarylbutyric acid as matrix metall Derivatives of substituted 4-biarylbutyric acid as matrix metall

1995-11-06

1998-08-04

Dees, Jose G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514423, 548473, 548478, 548533, A61K 31405, A61K 3140, C07D20948, C07D20708

Patent

active

057894345

ABSTRACT:
Inhibitors for matrix metalloproteases, pharmaceutical compositions containing them, and a process for using them to treat a variety of physiological conditions. The presently claimed compounds have the generalized formula ##STR1## in which each T represents a substituent group; x is 0, 1, or 2; D represents ##STR2## .delta. is 0 or 1; U' represents O, S, or N, with the proviso that when U' is N, then .delta.=0, and when U' is O or S, then .delta.=1; R.sup.14 is any of a variety of substituent groups; and G represents M, ##STR3## in which M represents --CO.sub.2 H, --CON(R.sup.11).sub.2, or --CO.sub.2 R.sup.12, R.sup.11 represents H or an alkyl group, R.sup.12 represents an alkyl group, and R.sup.13 represents any of the side chains of the 19 noncyclic naturally occurring amino acids; and pharmaceutically acceptable salts thereof.

REFERENCES:
patent: 5177204 (1993-01-01), Kuchar et al.
Child et al., Arzneim. Forsch., vol. 30, No. 1, pp. 695-702, 1980.

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