Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1997-07-21
1999-12-07
Davenport, Avis M.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 14, 530313, 530324, 530327, 530403, A61K 3800, C07K 500, C07K 700
Patent
active
05998368&
ABSTRACT:
There are provided novel compounds for the treatment of male impotence. The compounds are derived from vasoactive intestinal peptide (VIP) in which the natural amino acid sequence is modified by replacement of any of the 5, 17 and 19 amino acid residues by other natural or non-natural amino acids, and they bear at least one terminal lipophilic group.
The modified VIP sequences are prepared by conventional peptide chain assembling methods.
The novel compounds and compositions containing them are suitable for transdermal application for treating male impotence.
REFERENCES:
patent: 3879371 (1975-04-01), Said et al.
patent: 3880826 (1975-04-01), Said et al.
patent: 4016258 (1977-04-01), Said et al.
patent: 4605641 (1986-08-01), Bolin et al.
patent: 4732892 (1988-03-01), Sarpotdar et al.
patent: 4734400 (1988-03-01), Bolin et al.
patent: 4757133 (1988-07-01), Ito et al.
patent: 5147855 (1992-09-01), Gozes et al.
Werner, Haim et al., "High Levels of Vasoactive Intestinal Peptide in Human Milk," Biochemical and Biophysical Research Communications, vol.:133, No. 1, pp. 228-232, (1985).
Sachs, B.D., "Potency and Fertility: Hormonal and Mechanical Causes and Effects of Penile Actions in Rats," Hormones and Behaviour in Higher Vertebrates, pp. 86-110, (1983).
Merrifield, R.B., "Solid Phase Peptide Synthesis. I. The synthesis of a Tetrapeptide" J. Am. Chem. Soc., vol. 85, pp. 2149-2154, (1963).
Okumura, Mutsuo et al, "Effect of Several Enhancers on the Skin Permeation of Water-Soluble Drugs," Chem. Pharm. Bull., vol. 37, No. 5, pp. 1375-1378, (1989).
Gu, J. et al, "Decrease of Vasoactive Intestinal Polypeptide(VIP) in the Penises from Impotent Men," The Lancet, pp. 315-317, (1984).
Ottesen, Bent et al, "Penile Erection: possible role for vasoactive intestinal polypeptides as neuro-transmitter," British Medical Journal, vol. 288, pp. 9-11, (1984).
Dixson, A.F. et al, "Effects of tactile and electrical stimuli upon release of vasoactive intestinal polypeptide in the mammalian penis," Journal of Endocrinology, vol. 100, pp. 249-252, (1983).
Anderson, P-O et al, "Haemodynamics of pelvic nerve induced penile erection in the dog: possible mediation vasoactive intestinal polypeptide," Journal of Physiology, vol. 350, pp. 209-224, (1984).
Gozes, Illana et al, "Vasoactive Intestinal Peptide Potentiates Sexual Behavior: Inhibition by Novel Antagontist*," Endocrinology, vol. 125, No. 6, pp. 2945-2949, (1989).
Said, Sami I. et al, "Potent Peripheral and Splanchic Vasodilator Peptide from Normal Gut," Nature, vol. 225, pp. 863-864, (1970).
Rosenblatt, J. Biol. Chem., vol. 251, No. 1, pp. 159-164, 1976.
Gozes et al., J. Clinical Investigation, vol. 90, pp. 810-814 (1992).
Wagner, G. et al, "Intracavernosal injection of vasoactive intestinal polypeptide (VIP) does not induce erection in man per se.", World J. Urol., vol. 5, pp. 171-177 (1987).
Bodanzky et al, "The Vasoactive Intestinal Peptide (VIP) VI. The 27-Norleucine Analog of the Sequence 14-28", Bioorganic Chemistry, 3:320-323 (1974).
Wendleberger et al, "Total Synthesis of the 17-Norleucine Analogue of Porcine VII", pp. 290-295 (1980).
Fridkin Matityahu
Gozes Illana
Davenport Avis M.
Ramot University Authority for Applied Research and Industrial
Yeda Research and Development Co. Ltd.
LandOfFree
Derivatives of structurally modified VIP and pharmaceutical comp does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Derivatives of structurally modified VIP and pharmaceutical comp, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Derivatives of structurally modified VIP and pharmaceutical comp will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-823773