Derivatives of ryanodine and dehydroryanodine

Details Derivatives of ryanodine and dehydroryanodine Derivatives of ryanodine and dehydroryanodine

1996-04-23

1997-10-21

McKane, Joseph

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514 64, 514387, A61K 3140

Patent

active

056797010

ABSTRACT:
Novel O.sub.10eq -derivatives of ryanodine and dehydroryanodine characterized as binding strongly to ryanodine receptor, useful in affecting Ca.sup.++ efflux in tissue and also in isolating ryanodine receptor from sarcoplasmic reticulum. Also described are novel radio-iodinated alanine derivatives useful to radio label ryanodine and dehydroryanodine derivatives.

REFERENCES:
CA 118:147861v Ester derivatives of ryanodine and dehydroryanodine. Gerzon et al., p. 870, 1993.

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