Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1986-04-18
1989-08-08
Bond, Robert T.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546 18, 546 19, C07D49720, A61K 31435
Patent
active
048552909
ABSTRACT:
Quinuclidine derivatives having the general formula (I) ##STR1## and geometrical isomers, enantiomers, diastereoisomers, racemates and/or acid addition salts thereof, wherein Z represents the group >CR.sup.1 R.sup.2 or two hydrogen atoms; and R.sup.1 and R.sup.2, which may be identical or different, are each alkyl, cyclopentyl, cyclohexyl, aryl, or diarylmethylol, or alkyl which is substituted by one or more aryl groups, or one of R.sup.1 and R.sup.2 may be hydrogen.
REFERENCES:
patent: 4104397 (1978-08-01), Cohen et al.
Noller, "Chemistry of Organic Compounds", 2nd edition (1957) (Saunders) pp. 203-204, 278, 744-745.
Royals, "Advanced Organic Chemistry" (1954) (Prentice-Hall) pp. 627-639.
Mar., "Advanced Organic Chemistry" (1968) (McGraw-Hill) pp. 319, 328, 661, 662, 655.
Takemura et al., "Synthesis and Selective Activity of Cholinergic Agents with Rigid Skeletons II", 29 Chem. Pharm. Bull., No. 10, pp. 3019-3025.
Fisher Abraham
Grunfeld Yona
Heldman Eliahu
Karton Ishai
Levy Aharon
Bond Robert T.
State of Israel, represented by Prime Minister's Office, Israel
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