Derivatives of pyrimido[6, 1-A]isoquinolin-4-one

Details Derivatives of pyrimido[6, 1-A]isoquinolin-4-one Derivatives of pyrimido[6, 1-A]isoquinolin-4-one

2008-05-27

2008-05-27

Wilson, James O. (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S252010

Reexamination Certificate

active

07378424

ABSTRACT:
The invention provides compounds or salts thereof of the general formula (I):wherein each of R1and R2independently represents a C1-6alkyl or C2-7acyl group; X represents OCH2or a group CR3R4; wherein each of R3or R4independently represents a hydrogen atom or a C1-3alkyl group; R5represents a hydrogen atom or a C1-3alkyl, C2-3alkenyl or C2-3alkynyl group; R6represents a hydrogen atom or a C1-6alkyl, C2-6alkenyl, C2-6alkynyl, amino, C1-6alkylamino, di(C1-6) alkylamino or C2-7acylamino group; each of R7and R8independently represents a hydrogen or halogen atom or a hydroxy, trifluoromethyl, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C2-7acyl, C1-6alkylthio, C1-6alkoxy, C3-6cycloalkyl; and R9represents a hydrogen or halogen atom or a hydroxy, trifluoromethyl, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C2-7acyl, C1-6alkylthio, C1-6alkoxy or C3-6cycloalkyl group. The compounds or salts thereof are useful for treatment of respiratory disorders such as asthma. Compounds of the invention have a longer duration of action than the known compound trequinsin (9,10-dimethoxy-3 methyl-2-mesitylimino-2, 3,6,7-tetrahydro-4H-pyrimido[6,1-a]isoquinolin-4-one).

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