Derivatives of pyrimidinyl-piperazinyl-alkyl azoles with anxioly

Details Derivatives of pyrimidinyl-piperazinyl-alkyl azoles with anxioly Derivatives of pyrimidinyl-piperazinyl-alkyl azoles with anxioly

1990-02-07

1992-07-07

Fan, Jane T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

544295, A61K 31505, C07D40314

Patent

active

051283433

ABSTRACT:
The present invention relates to heterocyclic compounds characterized in that they correspond to the general formula I: ##STR1## in which R.sub.1 represents a hydrogen atom or a halogen, n can have the values 1 to 6 and Het represents an azole, or one of its derivatives selected from among imidazole, indazole, tetrahydroindazoles, pyrazole or pyrazoline and which can be represented by the general formula II: ##STR2## in which A and B, always different, represent a carbon atom or a nitrogen atom, the dashed line indicates the possible presence of a double bond between positions 4 and 5, and R.sub.2, R.sub.3 and R.sub.4, identical or different, and can also form a part of another ring, aromatic or not, represent a hydrogen atom, a halogen, a lower alkyl radical, a nitro radical, a hydroxyl radical, an oxo radical, an alkoxy radical, a cyano radical, a carboxylic radical, a carboxamido radical, an alkyl carboxylate radical, an aryle or substituted aryl radical, or an amino radical, of general formula III: ##STR3## in which R.sub.5 and R.sub.6, identical or different, represent a hydrogen atom, an alkyl radical, an aryl radical, a heteroaryl radical, an alkenyl radical, an alkylcarboxy radical, an arylcarboxy radical, an alkylsulfonyl radical or an arylsulfonyl radical.

REFERENCES:
patent: 4367335 (1983-01-01), Temple, Jr. et al.
patent: 4487773 (1984-12-01), Temple, Jr. et al.
patent: 4547499 (1985-10-01), Hester, Jr.
patent: 4675403 (1987-06-01), Abou-Gharbia et al.
European Journal of Medicinal Chemistry, vol. 22, No. 4, Jul.-Aug. 1987, pp. 337-345.

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