Derivatives of pyrido [2,3-D] and [3,2-D] pyrimidine method of u

Details Derivatives of pyrido [2,3-D] and [3,2-D] pyrimidine method of u Derivatives of pyrido [2,3-D] and [3,2-D] pyrimidine method of u

1999-11-03

2000-09-05

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514256, 514257, A61K 31505

Patent

active

061143391

ABSTRACT:
The invention also discloses compounds and pharmaceutically acceptable salts having the generic formula (2) ##STR1## wherein X and Y may be the same or different and are selected from the group consisting of OH and NH.sub.2 ; wherein Z is one of either nitrogen or carbon and Q is one of either nitrogen or carbon but when Z equal nitrogen, Q does not equal nitrogen and when Q equals nitrogen, Z does not equal nitrogen; wherein A is selected from the group consisting of nitrogen, carbon and sulfur and B equals carbon when A is selected from the group consisting of sulfur, carbon, and nitrogen, B equals nitrogen when A equals carbon and B equals sulfur when A equals carbon; wherein R.sub.3 is one of either hydrogen or methyl except where Z is nitrogen wherein R.sub.3 is zero; wherein R.sub.4 is one of either a hydrogen or a first lower alkyl group except when A equals sulfur wherein R.sub.4 is zero; wherein R.sub.1 is selected from the group consisting of hydrogen, nitroso group, aldehyde, a second lower alkyl group except when B is equal to sulfur wherein R.sub.1 is zero; and wherein R.sub.2 is selected from the group consisting alkyl, dialkyl and trialkyl groups, alkylaryl, diaryl and triaryl groups, substituted aryl, diaryl and triaryl groups, an alkoxy, substituted alkoxy and halogen.

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