Derivatives of pyrido [2,3-d] and [3,2-d] pyrimidine and methods

Details Derivatives of pyrido [2,3-d] and [3,2-d] pyrimidine and methods Derivatives of pyrido [2,3-d] and [3,2-d] pyrimidine and methods

1994-09-12

1996-04-16

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544279, A61K 31505, C07D47104

Patent

active

055082815

ABSTRACT:
The invention discloses generic compound (2) and its analog (6) and pharmaceutically acceptable salts and methods of using these compounds for therapeutically and prophylactically treating a patient for an illness consisting of the group of Pneumocystis carinii and Toxoplasmosis gondii ##STR1## In compound (2), X and Y may be the same or different and are selected from the group consisting of OH and NH.sub.2 ; Z is one of either nitrogen or carbon and Q is one of either nitrogen or carbon, but when Z equals nitrogen, Q does not equal nitrogen, and when Q equals nitrogen, Z does not equal nitrogen; A is selected from the group consisting of nitrogen, carbon and sulfur and B equals carbon when A is selected from the group consisting of sulfur, carbon and nitrogen, B equals nitrogen when A equals carbon and B equals sulfur when A equals carbon; .sub.3 is one of either hydrogen or methyl except where Z is nitrogen wherein R.sub.3 is zero; R.sub.4 is one of either a hydrogen or a first lower alkyl group except when A equals sulfur wherein R.sub.4 is zero; R.sub.1 is selected from the group consisting of hydrogen, nitroso group, aldehyde, a second lower alkyl group except when B is equal to sulfur wherein R.sub.1 is zero; and R.sub.2 is selected from the group consisting alkyl, dialkyl and trialkyl groups, alkylaryl, diaryl and triaryl groups, substituted aryl, diaryl and triaryl groups, an alkoxy, substituted alkoxy and halogen.

REFERENCES:
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