Derivatives of pravastatin for inhibiting cholesterol biosynthes

Details Derivatives of pravastatin for inhibiting cholesterol biosynthes Derivatives of pravastatin for inhibiting cholesterol biosynthes

1989-04-17

1991-09-10

Lee, Mary C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

540596, 544 587, 544149, 544333, 544405, 546207, 546268, 548204, 548214, 548236, 548300, 548517, 549 60, 549292, 424 11, C07D40512

Patent

active

050475495

ABSTRACT:
Derivatives of pravastatin are provided which are useful in inhibiting cholesterol biosynthesis and in preparing radiolabeled compounds useful in the radioimmunoassay (RIA) of pravastatin and derivatives thereof. The pravastatin derivatives have the structure ##STR1## wherein R is hydroxy, lower alkylamine, arylamine, arylalkylamine or heterocyclic alkylamine such as histamine, tyramine, O-benzyltyramine, methyl tyrosinate as well as iodinated derivatives thereof.

REFERENCES:
patent: 4346227 (1982-08-01), Terahara

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