Derivatives of pravastatin for inhibiting cholesterol biosynthes

Details Derivatives of pravastatin for inhibiting cholesterol biosynthes Derivatives of pravastatin for inhibiting cholesterol biosynthes

1988-03-21

1989-08-15

Schwartz, Richard A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

5142278, 5142315, 514252, 514256, 514319, 514336, 514365, 514372, 514374, 514385, 514397, 514422, 514444, 514459, 540596, 544 587, 544149, 544335, 544358, 546206, 546268, 548204, 548214, 548236, 548300, 548336, 548517, 549 60, 549292, A61K 3155, C07D40512

Patent

active

048575224

ABSTRACT:
Derivatives of pravastatin are provided which are useful in inhibiting cholesterol biosynthesis and in preparing radiolabeled compounds useful in the radioimmunoassay (RIA) of pravastatin and derivatives thereof. The pravastatin derivatives have the structure ##STR1## wherein R is hydroxy, lower alkylamine, arylamine, arylalkylamine or heterocyclic alkylamine such as histamine, tyramine, O-benzyltyramine, methyl tyrosinate as well as iodinated derivatives thereof.

REFERENCES:
patent: 4346227 (1982-08-01), Terahara et al.
patent: 4733003 (1988-03-01), Ide et al.

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