Derivatives of pravastatin and method of making the same

Details Derivatives of pravastatin and method of making the same Derivatives of pravastatin and method of making the same

1991-07-01

1992-10-13

Ivy, C. Warren

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

5483111, 549292, 560119, 562455, 562457, 562458, 562467, C07D23364

Patent

active

051552299

ABSTRACT:
Derivatives of pravastatin are provided which are useful in inhibiting cholesterol biosynthesis and in preparing radiolabeled compounds useful in the radioimmunoassay (RIA) of pravastatin and derivatives thereof. The pravastatin derivatives have the structure ##STR1## wherein R is hydroxy, lower alkylamine, arylamine, arylalkylamine or heterocyclic alkylamine such as histamine, tyramine, O-benzyltyramine, methyl tyrosinate as well as iodinated derivatives thereof.

REFERENCES:
patent: 4346227 (1982-08-01), Terahara

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