Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1988-01-07
1989-11-28
Hollrah, Glennon H.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
544121, 544357, 544374, 544379, 544388, 544396, 544398, 544402, A61K 31495, C07D40506
Patent
active
048837970
ABSTRACT:
Derivatives of piperazine having the general formula ##STR1## wherein R.sub.1 is benzhydryl or cinnamyl and R.sub.2 is selected from the group consisting of ##STR2## --(CH.sub.2).sub.3 --R.sub.8, --CH.sub.2 NHR.sub.9, --CH.sub.2 NH.sub.2 and --COR.sub.10 ; wherein R.sub.3 is hydrogen, chloromethyl, (4-benzhydryl-1-piperazinyl) methyl, 4-morpholinylmethyl or 1-piperidinylmethyl, R.sub.4 is hydrogen, chloromethyl or carbethoxy, R.sub.5 and R.sub.6 taken together are an oxygen atom or the radical --O--(CH.sub.2).sub.2 --O--, R.sub.7 is methyl, phenyl or 2-thienyl, R.sub.8 is 4-morpholinyl, 1-piperidinyl or 4-benzhydryl-1-piperazinyl, R.sub.9 is 2-oxo-1- (pyrrolidinyl) acetyl, 2-hydroxybenzoyl or 4-sulfamoylbenzoyl, R.sub.10 is 2-oxo-1-(pyrrolidinyl)methyl or 4-sulfamoylphenyl and X is oxygen or NH; as well as methods for making the same and their use in a pharmaceutical composition is proposed. The compounds have cardiovascular properties and increasing effects on cerebral flow.
REFERENCES:
Vigelius et al., "Chemical Abstracts", vol. 81, 1984, col. 63680q.
Zikolova et al., "Chemical Abstracts", vol. 100, 1983, col. 100:6454f.
Kaneko et al., "Chemical Abstracts", vol. 105, 1986, col. 105:105702z.
Kimura et al., "Chemical Abstracts", vol. 106, 1986, col. 106:224372t.
Foguet et al., "Chemical Abstracts", vol. 108, 1983, col. 108:167504c.
Foguet Rafael
Gubert Santiago
Ortiz José A.
Raga Manuel M.
Sacristan Aurelio
Ferrer Internacional S.A.
Hollrah Glennon H.
Striker Michael J.
Turnipseed James H.
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