Derivatives of phenoxy isobutyric acid having hypolipemizing and

Details Derivatives of phenoxy isobutyric acid having hypolipemizing and Derivatives of phenoxy isobutyric acid having hypolipemizing and

1975-05-14

1976-10-19

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

2602955A, C07D21356, A61K 31455, C07D21390

Patent

active

039871754

ABSTRACT:
The present invention relates to new chemical products which are useful as hypolipemizing and hypocholesterolemizing agents.
The new compounds are derivatives of phenoxy isobutyric acid of the general formula ##EQU1## wherein: A is a lower-alkylene bridge of 2 to 6 carbon atoms, either linear or branched,
X is a halogen atom,
R = h or lower-alkyl,
The N of the pyridyl ring can be replaced by an N-oxide, or the compounds can be in the form of their pharmaceutically-acceptable acid addition salts.
Pharmaceutical compositions containing these active principles are useful for hypolipemizing and hypocholesterolemizing purposes, e.g., in the prevention and treatment of atherosclerosis and its consequences.

REFERENCES:
patent: 3622587 (1971-11-01), Carlson et al.
patent: 3723446 (1973-03-01), Scherm et al.
patent: 3770753 (1973-11-01), Beaufour

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