Derivatives of penem

Details Derivatives of penem Derivatives of penem

1989-12-07

1992-01-07

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D49900, A61K 31425

Patent

active

050793578

ABSTRACT:
New derivatives of penem and pharmacutically acceptable salt thereof are herein disclosed; these compounds being useful as an antibacterial agent which has an extremely wide antibacterial spectrum, exhibits a high sensitivity to bacteria resistant to conventional penicillins and cephalosporin antibiotics and is excellent in its physico-chemical stability, solubility to water and biological stability, in particular, stability to decomposition by enzyme such as dehydropeptidase I in kidney, .beta.-lactamase; these derivatives of penem being able to be prepared by reacting 2-substituted sulfinyl derivative of penem with a thiol compound and then optionally removing protective group(s) and further alkylating the reaction product or vice versa.

REFERENCES:
patent: 4650794 (1987-03-01), Christensen et al.
patent: 4729990 (1988-03-01), Alpegiani et al.
patent: 4748162 (1988-05-01), Leanza et al.
patent: 4863914 (1989-09-01), Perrone et al.
patent: 4962202 (1990-10-01), Sato et al.
Derwent Publication 83-760170/37.
Derwent Publication 85-2463531/24.
Derwent Publication 86-009084/02.

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