Derivatives of naphthalene with COMT inhibiting activity

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C514S311000, C514S646000, C514S693000, C514S715000, C546S139000, C546S152000, C564S305000, C568S425000, C568S633000

Reexamination Certificate

active

06903114

ABSTRACT:
Compounds of formula (I′), wherein A, R1to R3and t are as defined in the disclosure, exhibit COMT enzyme inhibiting activity so that they are useful as COMT inhibitors.

REFERENCES:
patent: 3973608 (1976-08-01), Umezawa et al.
patent: 5389653 (1995-02-01), Bernauer et al.
patent: 5446194 (1995-08-01), Bäckström et al.
patent: 5650439 (1997-07-01), Nakamura et al.
patent: 5780675 (1998-07-01), Royer et al.
patent: 6150412 (2000-11-01), Pystynen et al.
patent: WO 96/37456 (1996-11-01), None
patent: WO 98/27973 (1998-07-01), None
Stipanovic et al, Phytochemistry, vol 19 No. 8, pp. 1735-8, 1980.
Abraham et al, Phytochemistry, vol 52, No. 5, pp. 829-836, 1999.
Guo et al, Chemical Abstracts, Abstract No. 108:204, 394, Jun. 11, 1988.
Servin et al., “Metabolism of 6,7-dimethoxy 4-(4′-chlorobenzyl)isoquinoline. II. Role of liver catechol O-methyltransferase and glutathione,” Xenobiotica, vol. 17, pp. 1381-1391 (1987).
Smit et al., “Catechol-O-Methyltransferase as a Target for Melanoma Destruction?,” Biochemical Pharmacology, vol. 48, pp. 743-752 (1994).
Lautala et al., “Molecular Mechanisms Controlling the Rate and Specificity of Catechol O-Methylation by Human Soluble Catechol O-Methyltransferase,” Molecular Pharmacology, vol. 59, pp. 393-402 (2001).
Lombardi et al., “Enzymatic Methylation of Microsomal Metabolites of Benzo(a)pyrene,” Cancer Research, vol. 41, pp. 4415-4419 (1981).
Kaakkola, “Clinical Pharmacology, Therapeutic Use and Potential of COMT Inhibitors in Parkinson's Disease,” Drugs, vol. 59, pp. 1233-1250 (2000).
Borchardt et al., “Catechol O-Methyltransferase. 12. Affinity Labeling the Active Site with the Oxidation Products of 5,6-Dihydroxyindole”, J. Med. Chem., vol. 25, pp. 263-271 (1982).
Lotta et al., “Kinetics of Human Soluble and Membrane-Bound Catechol O-Methyltransferase: A Revised Mechanism and Description of the Thermolabile Variant of the Enzyme”, Biochemistry, vol. 34, pp. 4202-4210 (1995).
Smissman et al., “Synthesis and Biological Activity of 2- and 4-Substituted 6,7-Dihydroxy-1,2,3,4-tetrahydroisoquinolines”, Journal of Medicinal Chemistry, vol. 19, No. 1, pp. 127-131 (1976).
Borchardt et al., “Catechol O-Methyltransferase. 8. Structure-Activity Relationships for Inhibition by 8-Hydroxyquinolines”, Journal of Medicinal Chemistry, vol. 19, No. 4, pp. 558-560 (1976).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Derivatives of naphthalene with COMT inhibiting activity does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Derivatives of naphthalene with COMT inhibiting activity, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Derivatives of naphthalene with COMT inhibiting activity will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3482168

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.