Derivatives of N,N-(2-chloro-ethyl)-phosphoric acid amide

Details Derivatives of N,N-(2-chloro-ethyl)-phosphoric acid amide Derivatives of N,N-(2-chloro-ethyl)-phosphoric acid amide

1986-04-30

1988-04-19

Sutto, Anton H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Phosphorus esters

558199, 260403, C07F 924

Patent

active

047390956

ABSTRACT:
The invention concerns derivatives of N,N-bis(2-chloroethyl)-phosphoric acid amide of general formula I ##STR1## wherein X and Y are the same or different and signify oxygen or NR.sup.3, R.sup.1 and R.sup.2 are the same or different and R.sup.1 signifies the radical CH.sub.2 (OR.sup.4)--CH.sub.2 --CH.sub.2 --, CH.sub.2 (OR.sup.4)--CH(CH.sub.3)--CH.sub.2 -- or CH.sub.2 (OR.sup.4)--CH(OR.sup.5)--CH.sub.2 -- and, when X is an NR.sup.3 group, can also be hydrogen, R.sup.2 possesses one of the meanings of R.sup.1 or is ethyl, propyl, allyl, propenyl, chloroethyl, methyl or benzyl, R.sup.3 is hydrogen, methyl, ethyl, propyl or allyl and wherein the radicals R.sup.4 and R.sup.5 are the same or different and represent an alkyl radical R or an acyl radical --COR, whereby R signifies a straight-chained or branched, saturated or unsaturated alkyl group with 1 to 25 carbon atoms, or an aralkyl radical with 1 to 25 carbon atoms in the alkyl chain, and one of the radicals can also be a hydrogen atom, as well as processes for their preparation. The compounds according to the invention display an outstanding antitumour action comparable with the action of cyclophosphamide.

REFERENCES:
patent: 3035080 (1962-05-01), Arnold et al.
Arnold et al, "Angewante Chemie", Bard 70, Nr 17/18, Sep. 23, 1958, pp. 5544.
Kosolapoff, "Organophosphorus Compounds"(1955), pp. 279-288.

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