Derivatives of N -heterocyclylmethylbenzamides, preparation...

Details Derivatives of N -heterocyclylmethylbenzamides, preparation... Derivatives of N -heterocyclylmethylbenzamides, preparation...

2007-09-20

2009-11-17

Seaman, D. Margaret (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C514S305000

Reexamination Certificate

active

07619089

ABSTRACT:
The invention relates to compositions comprising a compound having general formula (I):Wherein R, R1, R2, X and n are as described herein. Also disclosed and claimed in certain of the embodiments herein are the methods of preparation of compound of formula (I) and its use in therapeutics.

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Baur, et. al., Catalytic Asymmetric Protonation of Fluoro-Enolic Species: Access to Optically Active 2-Fluoro-1-Tetralone, Tetrahedron: Asymmetry vol. 14, (2003) pp. 2755-2761.
Brunner, H., et. al., Alpha-Amino Acid Derivatives by Enantioselective Decarboxylation, Eur. J. Org. Chem. (2003) pp. 2854-2862.
Brunner, H., et. al., Asymmetric Catalysis, 131[+] Naproxen Derivatives by Enantioselective Decarboxylation, European Journal of Chem. (2000) pp. 2119-2133.
Gallardo, M.A., et. al., Influence of Hypo-Osmolality on the Activity of Short-Chain Neutral Amino Acid Carriers in Trout (Salmo trutta) Red Blood Cells, J. Membrance Biol. vol. 155, (1997) pp. 113-119.
Caulfield, W. L., et. al., The First Potent and Selective Inhibitors of the Glycine Transporter Type 2, Journal of Medicinal Chemistry (2001, pp. 2679-2682, vol. 44, No. 17).

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