Derivatives of N-heterocyclylmethylbenzamides, preparation...

Details Derivatives of N-heterocyclylmethylbenzamides, preparation... Derivatives of N-heterocyclylmethylbenzamides, preparation...

2007-10-30

2007-10-30

Seaman, D. Margaret (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

active

11404273

ABSTRACT:
The invention relates to a compound having general formula (I):Wherein R, R1, R2, X and n are as described herein. Also disclosed and claimed in certain of the embodiments herein are the methods of preparation of compound of formula (I) and its use in therapeutics.

REFERENCES:
patent: WO 99/45011 (1999-09-01), None
Brunner et al. , European Journal of Organic Chemistry, 2000, 2119-2133, p.2123.
Baur et al, Sep. 19, 2003, Tetrahedron Asymmetry, 14 (2003), 2755-2761, compound 22 p. 2757.
Brunner, H., et. al., Alpha-Amino Acid Derivatives by Enantioselective Decarboxylation, Eur. J. Org. Chem. (2003) pp. 2854-2862.
Gallardo, M.A., et. al., Influence of Hypo-Osmolality on the Activity of Short-Chain Neutral Amino Acid Carriers in Trout (Salmo trutta) Red Blood Cells, J. Membrane Blol. vol. 155, (1997) pp. 113-119.
Caulfield, W. L., et. al., The First Potent and Selective Inhibitors of the Glycine Transporter Type 2, Journal of Medicinal Chemistry (2001), vol. 44, No. 17, pp. 2679-2682.

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