Derivatives of N-alkyl imidazoles

Details Derivatives of N-alkyl imidazoles Derivatives of N-alkyl imidazoles

1977-01-19

1978-10-31

Trousof, Natalie

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

542413, 548341, C07D23360, A61K 31415

Patent

active

041235428

ABSTRACT:
Compounds of the formula ##STR1## wherein R is lower alkyl; R.sup.1 is substituted or unsubstituted phenyl or phenyl straight chain lower alkyl; R.sup.2 is substituted or unsubstituted phenyl, phenyl straight chain lower alkyl or phenyl straight chain lower alkenyl; and wherein said substitution, solely in the phenyl ring of the aforesaid groups, comprises one or more substituents independently selected from the group consisting of lower alkyl, lower alkoxy, halo and trifluoromethyl; X is oxygen or sulfur; n is an integer of from 1 to 4 with the proviso that n cannot be 1 when X is oxygen and R.sup.1 is phenyl or substituted phenyl; and the antimicrobial acid addition salts thereof are useful as antifungal antibacterial and antiprotozoal agents.

REFERENCES:
patent: 3658813 (1972-04-01), Godefroi et al.
patent: 3682951 (1972-08-01), Kreider
patent: 3717655 (1973-02-01), Godefroi et al.
patent: 3796704 (1974-03-01), Metzger et al.
Conant et al., The Chemistry of Organic Compounds, Revised Edition, p. 264, N.Y., MacMillan, 1939.

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