Derivatives of muramyl-peptides and of steroids having macrophag

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

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536 5, A61K 3156, C07J 900

Patent

active

046633111

ABSTRACT:
The invention relates to compounds resulting from a covalent conjugation of the muramyl-peptide and the steroid particularly with membranal tropism, such as cholesterol, a precursor of its biosynthesis, or a steroid which is derived therefrom including a hydroxyl or amine group. Suspensions of liposomes including these compounds have macrophage activating properties.

REFERENCES:
Parant et al., Infection and Immunity, 27(3), 826-831 (1980).
Masek et al., Experientia, 34(10), 1363-1364 (1978).
Lefrancier et al., Biol. Abstr., 69(6), 4239 (1980), Abst. No. 39606.

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