Derivatives of monosaccharides as cell adhesion inhibitors

Details Derivatives of monosaccharides as cell adhesion inhibitors Derivatives of monosaccharides as cell adhesion inhibitors

2006-02-28

2006-02-28

Wilson, James O. (Department: 1623)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C536S018700, C536S004100, C536S017200, C536S053000, C536S123000, C536S123100, C536S120000, C536S116000, C514S025000

Reexamination Certificate

active

07005516

ABSTRACT:
This invention relates generally to compounds and processes for synthesizing derivatives of 2-3-O-isopropylidene-α-L-xylo-2-hexulofuranosonic acid. The compounds of this invention are useful, inter-alia, for the inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies, including inflammatory and autoimmune diseases, such as bronchial asthma, rheumatoid arthritis, type I diabetes, multiple sclerosis, allograft rejection and psoriasis. This invention also relates to pharmacological compositions containing derivatives of 2-3-O-isopropylidene-α-L-xylo-2-hexulofuranosonic acid and the methods of treating such pathologies as listed above.

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