Derivatives of monophosphoryl lipid A

Details Derivatives of monophosphoryl lipid A Derivatives of monophosphoryl lipid A

1987-10-22

1991-01-22

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

530300, 530322, 530331, 536 177, 536 187, 536117, 546 22, 548119, 548413, 548414, C07F 9655, C07F 96558

Patent

active

049872370

ABSTRACT:
Novel derivatives of monophosphoryl lipid A and a process for their preparation are provided. The derivatives contain one or more free groups, such as an amine, on a side chain attached to the primary hydroxyl groups of the monophosphoryl lipid A nucleus through an ester group. The derivatives provide a convenient method for coupling the lipid A through coupling agents to various biologically active materials, substrates, and the like, wherein the immunostimulant properties of lipid A are desired.

REFERENCES:
patent: 4436727 (1984-03-01), Ribi
patent: 4437728 (1984-03-01), Ribi et al.
"Peptides as Requirements for Immunotherapy . . ." E. Ribi et al., Cancer Immunology & Immunotherapy, 1979--pp. 43-58.
"Heterogeneity & Biological Activity . . ." C. Chen et al., Journal of Infect. Diseases, 1973--pp. S43-S51.
"Beneficial Modification . . ." E. Ribi, Jour. Bio. Rspn., pp. 1-9.
"Chem. Comb. of Biol. Active Der . . .", Hasegawa et al., 1986, pp. 371-385.

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