Derivatives of mitomycin C

Details Derivatives of mitomycin C Derivatives of mitomycin C

1974-12-16

1977-05-03

Love, Ethel G.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424274, C07D20956

Patent

active

040214494

ABSTRACT:
1A-Higher aliphatic acyl derivatives of mitomycin C have been found to have superior anti-tumor activity and lipid-solubility as compared with known 1a-acyl derivatives of mitomycin C. Also, the new derivatives exhibit far lower toxicity than mitomycin C. These derivatives are represented by the following formula: ##STR1## wherein R is an aliphatic hydrocarbon group having 9-29 carbon atoms or a group wherein a hydrogen atom of the aliphatic hydrocarbon group is substituted by a hydroxy group.

REFERENCES:
patent: 3450705 (1969-06-01), Matsui et al.
patent: 3506681 (1970-04-01), Matsui et al.
patent: 3514452 (1970-05-01), Matsui et al.

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