Derivatives of midecamycine

Details Derivatives of midecamycine Derivatives of midecamycine

1976-06-30

1979-02-27

Raymond, Richard

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

Conjugated via claimed linking group, bond, chelating agent,...

536 9, 536 17, A61K 3170

Patent

active

041419715

ABSTRACT:
Novel derivatives of midecamycine, of the formula: ##STR1## wherein X represents an oxygen atom or a sulphur atom, R.sub.1 represents a straight or branched alkyl group, an alkenyl group or an aryl group, R.sub.2 represents a hydrogen atom or a lower acyl group, the dotted lines represent the possible presence of double bonds, it being understood that the 2 double bonds at the 10,11 position on the one hand and the 12,13 position on the other either exist simultaneously or neither of them exists, which give by oral administration plasma rates which are higher than midecamycine and which lack its bitter taste, together with their process of preparation.

REFERENCES:
patent: 3040025 (1962-06-01), Murphy et al.
patent: 3661891 (1972-05-01), Sinkula
Inouye et al., J. of Antibiotics, Jul. 1971, vol. 24, pp. 460-471.
Journal of Antibiotics, vol. 24, Jul.-Dec., 1971, pp. 457 and 480 (Table 4).
Journal of Antibiotics, vol. 29, No. 5, May, 1976, Japan Antibiotics Res. Assoc., pp. 536-548.

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