Derivatives of magainin and methods of production thereof

Details Derivatives of magainin and methods of production thereof Derivatives of magainin and methods of production thereof

2007-06-19

2007-06-19

Weber, Jon (Department: 1652)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C435S071300, C530S324000

Reexamination Certificate

active

10705106

ABSTRACT:
The present invention provides a Magainin derivative peptide and method of production thereof. Also provided is a pharmaceutically composition comprising said Magainin derivative peptide and pharmaceutically acceptable carrier and/or pharmaceutically compatible binding agents. The Magainin derivative peptide of the present invention having amino acid sequence of the general formula shown as below:     Gly-Ile-Gly-Lys-Phe-Leu-His-Ser-Ala-Lys-Lys-Phe-Gly-Lys-Ala-Phe-Val-Gly-Glu-Ile-X-Asn-Y-Z-OHin which: X is an amino acid residue selected from the group consisting of Met, Ile and Leu; Y is an amino acid residue selected from the group consisting of Ser, Lys, Ile, Arg and Leu; and Z is Arg.

REFERENCES:
patent: 5686563 (1997-11-01), Kari
patent: 5792831 (1998-08-01), Maloy
patent: 5912231 (1999-06-01), Houghten et al.
patent: 6461834 (2002-10-01), Dormady et al.
Hwang et al. article entitled: “A Simple Method for the Purification of an Antimicrobial Peptide in RecombinantEscherichia coli” Molecular Biotechnology, vol. 18, 2001, pp. 193-198.
Lamb et al. article entitled: “Pexiganan Acetate”Drugs, Dec. 1998, 56 (6), pp. 1047-1052.

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