Derivatives of L-carnitine

Details Derivatives of L-carnitine Derivatives of L-carnitine

1988-12-08

1989-11-28

Shippen, Michael L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514274, 514554, 514555, 536 27, 544314, 562567, C07C10130, A61K 3119

Patent

active

048837865

ABSTRACT:
Novel derivatives of L-carnitine or of L-acylcarnitines or of esters thereof, obtained by salification with suitable acids or acidic aminoacids, monosalified with potassium ion.
These derivatives show cardiotropic properties in the therapy of myocardial anoxia, of ischemia, of arrythmic syndromes, of cardiac failures in general and in cases of increased energy request due to fatigue at cardiac and muscular level.

REFERENCES:
patent: 3088871 (1963-05-01), Pfeiffer
patent: 3903147 (1975-09-01), Kyncl
patent: 4075352 (1978-02-01), De Felice
patent: 4161523 (1979-07-01), Weinstein
patent: 4401827 (1983-08-01), Witt
patent: 4567200 (1986-01-01), Tinti
patent: 4649159 (1987-03-01), Fancelli
Goodman, "The Pharmacological Basis of Therapeutics", pp. 795-806 (1955).
Wilson, "Textbook of Organic Medical and Pharmaceutical Chemistry", p. 39 (1954).
"The Merck Index", 9th Ed., pp. 21, 892 & 893 (1976).
Hosein, Chem. Abstr., 67: 31250 (1967).

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