Derivatives of L- and DL-4-hydroxyphenylglycine

Details Derivatives of L- and DL-4-hydroxyphenylglycine Derivatives of L- and DL-4-hydroxyphenylglycine

1978-10-30

1980-08-19

Demers, Arthur P.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

2601125R, 260559A, 424177, 424324, 562444, 562445, 562448, C07C10352, C07C10328

Patent

active

042184746

ABSTRACT:
L- and DL-isomers of compounds of the formula ##STR1## and the pharmaceutically acceptable salts thereof, wherein R is hydrogen or methyl; R.sup.1 is alkynyl, alkenyl or cycloalkyl, each having from three to seven carbon atoms or alkyl having from one to six carbon atoms which may optionally be substituted by one or more groups selected from hydroxy, alkoxy, carboxy, amino, monoalkylamino, dialkylamino, phenyl and phenoxy, any such phenyl or phenoxy being optionally substituted with one or more hydroxy, alkyl or alkoxy groups, said alkyl and alkoxy optional substituents having from one to six carbon atoms; provided that R.sup.1 is other than 4-hydroxy-.alpha.-carboxybenzyl or 4-methoxy-.alpha.-carboxybenzyl. Said compounds are useful in treating diseases and conditions characterized by reduced blood flow, oxygen availability or carbohydrate metabolism in the cardiovascular system. The D-isomers of the compounds of formula (II) are substantially inactive in treating such diseases and conditions.

REFERENCES:
patent: 2833764 (1958-05-01), Baker et al.
patent: 2868818 (1959-01-01), Pfister et al.
patent: 3725470 (1973-04-01), Bretschneider et al.
patent: 4087520 (1978-05-01), Braun et al.
patent: 4093653 (1978-06-01), Boesten
patent: 4111981 (1978-09-01), Greason
patent: 4148920 (1979-04-01), Barnish et al.
Teraoa et al., J. Biochem (Japan), 70 (1971), pp. 133-142.
Flouret et al., J. Med. Chem., 1973, vol. 16, pp. 369-372.

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